{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T14:49:00Z","timestamp":1787496540596,"version":"build-2736575974"},"reference-count":28,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100008664","name":"Juvenile Diabetes Research Foundation United Kingdom","doi-asserted-by":"publisher","award":["2\u2010SRA\u20102018\u2010474\u2010S\u2010B"],"award-info":[{"award-number":["2\u2010SRA\u20102018\u2010474\u2010S\u2010B"]}],"id":[{"id":"10.13039\/100008664","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000361","name":"Diabetes UK","doi-asserted-by":"publisher","award":["16\/0005480"],"award-info":[{"award-number":["16\/0005480"]}],"id":[{"id":"10.13039\/501100000361","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["dom-pubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabetes Obesity Metabolism"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims\/Hypothesis<\/jats:title>\n                    <jats:p>Raised levels of circulating interleukin\u20108 (IL\u20108) were reported in adults and children with type 1 diabetes (T1D). In this study, we measured IL\u20108 and IL\u20108 receptor expression levels in the pancreas, and IL\u20108 and myeloperoxidase (MPO) in the serum of recent\u2010onset T1D versus controls.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Pancreatic samples from donors with T1D within 2\u2009years of diagnosis and from non\u2010diabetic controls were obtained from a diabetes biobank. Serum was collected from individuals with newly diagnosed T1D within their first year of disease (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200942) and healthy controls (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200911). Serum IL\u20108 and myeloperoxidase were measured with an ELISA assay.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      IL\u20108 and IL\u20108 receptor gene expression were significantly increased in the pancreas of individuals with T1D compared to controls. Patients showed significantly increased IL\u20108 levels compared to controls. MPO levels were higher in T1D versus controls (median (IQR), 95\u2009327 [55718\u2013168\u2009974] vs. 42\u2009729 [24147\u201395\u2009327] pg\/mL,\n                      <jats:italic>p<\/jats:italic>\n                      \u2010value\u2009=\u20090.0349). T1D patients with IL\u20108 &gt;62\u2009pg\/mL showed higher levels of both HbA1c, and blood glucose compared to subjects with IL\u20108 levels \u226462\u2009pg\/mL (HbA1c (mmol\/mol); median [IQR], 100 [79.40\u2013122.8] vs. 79.50 [52.25\u201396.25]; HbA1c (%); median [IQR], 11.30 [9.52\u201313.38] vs. 9.45 [6.95\u201310.93],\n                      <jats:italic>p<\/jats:italic>\n                      \u2010value\u2009=\u20090.015) and, blood glucose; median [IQR], 360 [283\u2013488.5] vs. 243.5 [197.5\u2013314.5],\n                      <jats:italic>p<\/jats:italic>\n                      \u2010value\u2009=\u20090.019.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions\/Interpretation<\/jats:title>\n                    <jats:p>Our findings support an elevation of IL\u20108 in both pancreatic tissue and serum in recent\u2010onset T1D and suggest that higher IL\u20108 levels may be associated with poorer glycemic control. Further studies are needed to clarify the mechanistic role of IL\u20108 in T1D pathogenesis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/dom.70048","type":"journal-article","created":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T10:01:32Z","timestamp":1756720892000},"page":"6491-6498","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Raised levels of Interleukin\u20108 and myeloperoxidase in patients with recent onset type 1 diabetes"],"prefix":"10.1111","volume":"27","author":[{"given":"Ghadeer","family":"Alhamar","sequence":"first","affiliation":[{"name":"Unit of Endocrinology Fondazione Policlinico Universitario Campus Bio\u2010Medico  Rome Italy"},{"name":"Department of Immunology and Microbiology Dasman Diabetes Institute  Kuwait City Kuwait"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Fallucca","sequence":"additional","affiliation":[{"name":"Unit of Endocrinology Fondazione Policlinico Universitario Campus Bio\u2010Medico  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah J.","family":"Richardson","sequence":"additional","affiliation":[{"name":"Islet Biology Exeter (IBEx), Exeter Centre of Excellence for Diabetes Research (EXCEED), Department of Clinical and Biomedical Sciences University of Exeter Medical School  Exeter UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Forough","family":"Torabi","sequence":"additional","affiliation":[{"name":"School of Life and Environmental Sciences University of Lincoln  Lincoln UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael R.","family":"Christie","sequence":"additional","affiliation":[{"name":"School of Life and Environmental Sciences University of Lincoln  Lincoln UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jayakumar","family":"Vadakekolathu","sequence":"additional","affiliation":[{"name":"John van Geest Cancer Research Centre, Nottingham Trent University  Nottingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David J.","family":"Boocock","sequence":"additional","affiliation":[{"name":"John van Geest Cancer Research Centre, Nottingham Trent University  Nottingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia","family":"Pieralice","sequence":"additional","affiliation":[{"name":"Unit of Endocrinology Fondazione Policlinico Universitario Campus Bio\u2010Medico  Rome Italy"},{"name":"Department of Experimental Medicine Sapienza University of Rome  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia","family":"Manfrini","sequence":"additional","affiliation":[{"name":"Unit of Endocrinology Fondazione Policlinico Universitario Campus 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