{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T19:54:55Z","timestamp":1792007695924,"version":"4.4.0"},"reference-count":30,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2025,9,2]],"date-time":"2025-09-02T00:00:00Z","timestamp":1756771200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2025,9,2]],"date-time":"2025-09-02T00:00:00Z","timestamp":1756771200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["dom-pubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabetes Obesity Metabolism"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Metabolic dysfunction\u2010associated steatotic liver disease (MASLD) is prevalent among individuals with overweight or obesity and type 2 diabetes (T2DM), increasing the risk for liver\u2010related and cardiovascular complications. Lifestyle changes to reduce body weight are the primary intervention to decrease the risk of MASLD and liver fibrosis. This study aimed to evaluate the impact of a pharmacological intervention with naltrexone\/bupropion (NB) on hepatic steatosis and fibrosis risk in patients with T2DM using non\u2010invasive tests.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>In this post hoc analysis of a 56\u2010week, randomized, double\u2010blind, placebo\u2010controlled trial 505 adults with T2DM and overweight or obesity were randomized to either NB or placebo (2:1), both combined with structured lifestyle counselling. Hepatic outcomes were measured using the Hepatic Steatosis Index (HSI), Metabolic Dysfunction\u2010Associated Fibrosis\u20105 (MAF\u20105) and Fibrosis\u20104 (FIB\u20104) indices. Changes in liver\u2010related indices were analysed by treatment arm and weight loss strata (&lt;5%, \u22655%, \u226510%), and multivariable regression was used to identify predictors of hepatic improvement.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      At Week 56, the NB group achieved significantly greater body weight loss (\u22126.3\u2009\u00b1\u20097.2\u2009kg vs. \u22122.5\u2009\u00b1\u20095.2\u2009kg,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). Lifestyle intervention with NB treatment compared with placebo significantly reduced HSI (\u22122.9 vs. \u22121.2,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001) and MAF\u20105 (\u22120.80 vs. \u22120.31,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.003), while FIB\u20104 scores remained unchanged in both groups. The best improvements in HSI and MAF\u20105 were observed in those achieving \u22655% or\u2009\u2265\u200910% weight loss compared with those with &lt;5% (all\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). Weight change correlated strongly with HSI reduction (\n                      <jats:italic>r<\/jats:italic>\n                      \u2009=\u20090.796,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001) and moderately with MAF\u20105 (\n                      <jats:italic>r<\/jats:italic>\n                      \u2009=\u20090.488,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001), but not with FIB\u20104 (\n                      <jats:italic>r<\/jats:italic>\n                      \u2009=\u20090.034,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.590). Multiple regression analysis identified weight change as the strongest predictor of improvements in hepatic markers (HSI, MAF\u20105, ALT and AST), with no significant contributions from other factors.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Weight loss was the key driver of hepatic improvements in patients with T2DM and overweight or obesity. Treatment with NB resulted in significantly greater weight reduction and significantly greater improvements in HSI and MAF\u20105 compared with placebo, suggesting an added benefit for liver health.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/dom.70071","type":"journal-article","created":{"date-parts":[[2025,9,2]],"date-time":"2025-09-02T07:00:54Z","timestamp":1756796454000},"page":"6624-6631","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Assessing the effects of naltrexone\u2010bupropion on hepatic steatosis and fibrosis in patients with\n                    <scp>T2DM<\/scp>\n                    and overweight or obesity: Insights from a placebo\u2010controlled trial"],"prefix":"10.1111","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-9732-430X","authenticated-orcid":false,"given":"Alina N.","family":"Saidi","sequence":"first","affiliation":[{"name":"Department of Internal Medicine Franciscus Gasthuis &amp; Vlietland  Rotterdam The Netherlands"},{"name":"Department of Internal Medicine Erasmus Medical Center  Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura A. M.","family":"Konings","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Franciscus Gasthuis &amp; Vlietland  Rotterdam The Netherlands"},{"name":"Department of Internal Medicine Erasmus Medical Center  Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmen A. W.","family":"Dietvorst","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Franciscus Gasthuis &amp; Vlietland  Rotterdam The Netherlands"},{"name":"Department of Internal Medicine Erasmus Medical Center  Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vivian D.","family":"de Jong","sequence":"additional","affiliation":[{"name":"Julius Center for Health Science and Primary Care University Medical Center Utrecht  Utrecht The Netherlands"},{"name":"Julius Clinical  Zeist The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Willem Pieter","family":"Brouwer","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Erasmus Medical Center  Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aart\u2010Jan","family":"van der Lelij","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Erasmus Medical Center  Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Alings","sequence":"additional","affiliation":[{"name":"Department of Cardiology Amphia Hospital  Breda The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martien","family":"van Wenum","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Franciscus Gasthuis &amp; Vlietland  Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simone P.","family":"Rauh","sequence":"additional","affiliation":[{"name":"Department of Science Franciscus Gasthuis &amp; Vlietland  Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiwei","family":"Xu","sequence":"additional","affiliation":[{"name":"Julius Center for Health Science and Primary Care University Medical Center Utrecht  Utrecht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuel","family":"Castro Cabezas","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Franciscus Gasthuis &amp; Vlietland  Rotterdam The Netherlands"},{"name":"Department of Internal Medicine Erasmus Medical Center  Rotterdam The Netherlands"},{"name":"Julius Clinical  Zeist The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,9,2]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2024.04.031"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2023.04.036"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms221910541"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm14020428"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2024.03.006"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/obr.13481"},{"key":"e_1_2_10_8_1","unstructured":"WHO.Obesity statistics.2025. 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