{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T18:42:23Z","timestamp":1783363343668,"version":"3.54.6"},"reference-count":33,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T00:00:00Z","timestamp":1756252800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T00:00:00Z","timestamp":1756252800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["dom-pubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabetes Obesity Metabolism"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>The rising prevalence of overweight and obesity among Asian populations poses a critical public health concern. Semaglutide 2.4\u2009mg, a glucagon\u2010like peptide\u20101 receptor agonist, has demonstrated promising weight\u2010reduction effects in global populations, but its efficacy and safety profile in Asians remain less comprehensively examined. This meta\u2010analysis aimed to evaluate the effectiveness and tolerability of semaglutide 2.4\u2009mg compared to placebo in Asian individuals with overweight or obesity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>\n                      A systematic literature search was conducted in Medline, ScienceDirect, Europe pubMed central (PMC)\u00a0and the Cochrane Library up to 15 June 2025. Eligible studies were randomised controlled trials (RCTs) comparing semaglutide 2.4\u2009mg with placebo in overweight or obese Asian individuals. Risk of bias was evaluated using the Cochrane Risk of Bias v2 tool. Pooled outcomes were analysed using random\u2010effects models to estimate mean differences (MDs) and odds ratios, and heterogeneity was assessed with the\n                      <jats:italic>I<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      statistic.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Five RCTs involving 2614 participants met the inclusion criteria. All trials were deemed to have a low risk of bias. Our meta\u2010analysis indicated that treatment with semaglutide 2.4\u2009mg resulted in significantly greater reductions in body weight (MD: \u22128.20%; 95% confidence interval [CI]: \u221210.06 to \u22126.35;\n                      <jats:italic>I<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      \u2009=\u200984%), waist circumference (MD: \u22126.47\u2009cm; 95% CI: \u22128.26 to \u22124.68;\n                      <jats:italic>I<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      \u2009=\u200984%), body mass index (MD: \u22123.22\u2009kg\/m\n                      <jats:sup>2<\/jats:sup>\n                      ; 95% CI: \u22124.01 to \u22122.44;\n                      <jats:italic>I<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      \u2009=\u200966%) and systolic blood pressure (MD: \u22123.46\u2009mmHg; 95% CI: \u22125.29 to \u22121.62;\n                      <jats:italic>I<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      \u2009=\u200928%) compared to placebo. A higher proportion of participants in semaglutide 2.4\u2009mg achieved weight loss exceeding 5%, 10% and 15%. Gastrointestinal symptoms were the most commonly reported adverse effects, generally mild to moderate and self\u2010limiting.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Semaglutide 2.4\u2009mg significantly improves weight\u2010related and cardiometabolic outcomes in Asian adults with overweight or obesity. Further studies are warranted to assess long\u2010term effects, real\u2010world applicability and variability across subpopulations.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/dom.70073","type":"journal-article","created":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T09:53:36Z","timestamp":1756288416000},"page":"6632-6643","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Efficacy and safety of once\u2010weekly subcutaneous semaglutide 2.4\u2009mg for the management of overweight or obesity in Asian populations: A systematic review, meta\u2010analysis and meta\u2010regression of randomised trials"],"prefix":"10.1111","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0569-4617","authenticated-orcid":false,"given":"Hendra","family":"Zufry","sequence":"first","affiliation":[{"name":"Division of Endocrinology, Metabolism, and Diabetes, Thyroid Center, Department of Internal Medicine, 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