{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T15:04:28Z","timestamp":1791299068340,"version":"4.1.0"},"reference-count":63,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2025,9,3]],"date-time":"2025-09-03T00:00:00Z","timestamp":1756857600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,9,3]],"date-time":"2025-09-03T00:00:00Z","timestamp":1756857600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100020013","name":"NIHR Leicester Biomedical Research Centre","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100020013","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["dom-pubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabetes Obesity Metabolism"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>To evaluate whether weight\u2010loss interventions are associated with obesity\u2010associated cancers (OAC) in individuals with overweight\/obesity and type 2 diabetes (T2D).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>This retrospective cohort study utilised the TriNetX federated research network. Three cohorts of adults with overweight\/obesity and T2D, treated with either semaglutide, tirzepatide or bariatric surgery (BS) between June 2005 and June 2025, were propensity score matched (1:1) to cohorts treated with dipeptidyl peptidase\u20104 inhibitors (DPP\u20104i) using potential confounding factors. Using Cox regression analysis, we estimated hazard ratios (HRs) of composite and individual OAC: breast, colorectal, gallbladder, liver, multiple myeloma, oesophageal, ovarian, pancreatic, renal, gastric cardia, thyroid and uterine cancers.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>In 64,178 matched pairs (mean follow\u2010up 911\u2009days), semaglutide (vs. DPP\u20104i) was associated with lower rates of composite OAC (HR: 0.88; 95% CI: 0.82\u20130.95), colorectal (0.80; 0.67\u20130.97), liver (0.75; 0.60\u20130.95) and pancreatic (0.76; 0.60\u20130.96) cancers. In 19,682 matched pairs (mean follow\u2010up 435\u2009days), tirzepatide (vs. DPP\u20104i) was associated with a non\u2010significant lower rate of composite OAC (0.84; 0.69\u20131.01) but a significant lower rate of ovarian cancer (0.31; 0.10\u20130.95). In 9642 matched pairs (mean follow\u2010up 1746\u2009days), BS (vs. DPP\u20104i) was associated with lower rates of composite OAC (0.85; 0.74\u20130.98), liver (0.56; 0.32\u20130.97) and uterine cancers (0.59; 0.38\u20130.90), and higher rates of gastric cardia cancer (10.54; 1.35\u201382.38) and oesophageal cancer (4.78; 1.04\u201321.87).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Semaglutide and BS were associated with lower cancer rates in individuals with overweight\/obesity and T2D, with non\u2010significant lower rates also observed with tirzepatide. These findings suggest weight\u2010loss interventions may contribute to cancer prevention in this population.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/dom.70090","type":"journal-article","created":{"date-parts":[[2025,9,4]],"date-time":"2025-09-04T04:52:52Z","timestamp":1756961572000},"page":"6914-6926","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Weight loss interventions and obesity\u2010associated cancers in people with type 2 diabetes and overweight\/obesity: A real\u2010world observational study"],"prefix":"10.1111","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-3190-4975","authenticated-orcid":false,"given":"Testimony","family":"Ipaye","sequence":"first","affiliation":[{"name":"NIHR Leicester Biomedical Research Centre University Hospitals of Leicester NHS Trust  Leicester UK"},{"name":"Leicester Diabetes Centre Leicester General Hospital, University of Leicester  Leicester UK"},{"name":"Leicester Cancer Research Centre University of Leicester  Leicester UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8553-8296","authenticated-orcid":false,"given":"Jonathan","family":"Goldney","sequence":"additional","affiliation":[{"name":"NIHR Leicester Biomedical Research Centre University Hospitals of Leicester NHS Trust  Leicester UK"},{"name":"Leicester Diabetes Centre Leicester General Hospital, University of Leicester  Leicester UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas J.","family":"Wilkinson","sequence":"additional","affiliation":[{"name":"NIHR Leicester Biomedical Research Centre University Hospitals of Leicester NHS Trust  Leicester UK"},{"name":"Leicester Diabetes Centre Leicester General Hospital, University of Leicester  Leicester UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Zaccardi","sequence":"additional","affiliation":[{"name":"NIHR Leicester Biomedical Research Centre University Hospitals of Leicester NHS Trust  Leicester UK"},{"name":"Leicester Diabetes Centre Leicester General Hospital, University of Leicester  Leicester UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Yates","sequence":"additional","affiliation":[{"name":"NIHR Leicester Biomedical Research Centre University Hospitals of Leicester NHS Trust  Leicester UK"},{"name":"Leicester Diabetes Centre Leicester General Hospital, University of Leicester  Leicester UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9987-9371","authenticated-orcid":false,"given":"Melanie J.","family":"Davies","sequence":"additional","affiliation":[{"name":"NIHR Leicester Biomedical Research Centre University Hospitals of Leicester NHS Trust  Leicester UK"},{"name":"Leicester Diabetes Centre Leicester General Hospital, University of Leicester  Leicester UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen","family":"Brown","sequence":"additional","affiliation":[{"name":"NIHR Leicester Biomedical Research Centre University Hospitals of Leicester NHS Trust  Leicester UK"},{"name":"Leicester Cancer Research Centre University of Leicester  Leicester UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dimitris","family":"Papamargaritis","sequence":"additional","affiliation":[{"name":"NIHR Leicester Biomedical Research Centre University Hospitals of Leicester NHS Trust  Leicester UK"},{"name":"Leicester Diabetes Centre Leicester General Hospital, University of Leicester  Leicester UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,9,3]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0021-9681(72)90027-6"},{"key":"e_1_2_9_3_1","unstructured":"WorldHealthOrganization.Obesity. 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