{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T16:39:30Z","timestamp":1780504770240,"version":"3.54.1"},"reference-count":23,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2025,9,10]],"date-time":"2025-09-10T00:00:00Z","timestamp":1757462400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,9,10]],"date-time":"2025-09-10T00:00:00Z","timestamp":1757462400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100005024","name":"Beijing Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["2023\u2010ZZ\u2010001"],"award-info":[{"award-number":["2023\u2010ZZ\u2010001"]}],"id":[{"id":"10.13039\/501100005024","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012351","name":"Mitsubishi Tanabe Pharma Corporation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012351","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["dom-pubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabetes Obesity Metabolism"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>Sodium\u2010glucose cotransporter 2 (SGLT2) inhibitors consistently demonstrate renal protection against progressive kidney disease. We hypothesised that SGLT2 inhibition reduces blood glucose levels in peri\u2010proximal tubular capillaries by limiting reabsorption from the tubular filtrate, thereby safeguarding the renal microvasculature from hyperglycaemic stress.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>In anaesthetised streptozotocin\u2010induced type 1 and Otsuka\u2010Long Evans fatty (OLETF) type 2 diabetic rats, we measured the arterial\u2010to\u2010renal venous glucose ratio (RV\/A) to evaluate the effects of canagliflozin, a SGLT2 inhibitor.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>In fasting OLETF rats, three\u2010day oral canagliflozin treatment at both glycaemic and subglycaemic doses significantly lowered the RV\/A glucose ratio compared with vehicle. During anaesthesia, duodenal glucose infusion increased the RV\/A glucose ratio in diabetic OLETF rats, an effect prevented by canagliflozin but not by acute insulin infusion. Moreover, 4\u2010week canagliflozin therapy preserved renal capillary density more effectively than insulin in OLETF rats.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>These findings indicate that canagliflozin offers superior protection of the renal microvasculature from hyperglycaemic stress, independent of its systemic glucose\u2010lowering action.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/dom.70118","type":"journal-article","created":{"date-parts":[[2025,9,10]],"date-time":"2025-09-10T08:25:09Z","timestamp":1757492709000},"page":"7180-7188","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["An\n                    <scp>SGLT2<\/scp>\n                    inhibitor, canagliflozin, reduces blood glucose level in the renal capillaries and protects the capillary network in the diabetic rats"],"prefix":"10.1111","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-0753-0838","authenticated-orcid":false,"given":"Anqi","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Urology, Beijing Chao\u2010Yang Hospital Capital Medical University  Beijing China"},{"name":"Department of Pharmacology Kagawa University  Kagawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhicheng","family":"Bi","sequence":"additional","affiliation":[{"name":"Department of Pharmacology Kagawa University  Kagawa Japan"},{"name":"Institute of Urology Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8114-8952","authenticated-orcid":false,"given":"Satoshi","family":"Kidoguchi","sequence":"additional","affiliation":[{"name":"Department of Pharmacology Kagawa University  Kagawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akira","family":"Nishiyama","sequence":"additional","affiliation":[{"name":"Department of Pharmacology Kagawa University  Kagawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaopeng","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Urology, Beijing Chao\u2010Yang Hospital Capital Medical University  Beijing China"},{"name":"Institute of Urology Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daisuke","family":"Nakano","sequence":"additional","affiliation":[{"name":"Department of Pharmacology Kagawa University  Kagawa 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