{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T13:29:50Z","timestamp":1787318990505,"version":"build-2736575974"},"reference-count":42,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2025,9,12]],"date-time":"2025-09-12T00:00:00Z","timestamp":1757635200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,9,12]],"date-time":"2025-09-12T00:00:00Z","timestamp":1757635200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["dom-pubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabetes Obesity Metabolism"],"published-print":{"date-parts":[[2025,12]]},"abstract":"Abstract<\/jats:title>\n \n Aims<\/jats:title>\n \n To compare the effects of estetrol\/drospirenone (\n E4<\/jats:styled-content>\n \/\n DRSP<\/jats:styled-content>\n ) and ethinyl estradiol\/drospirenone (\n EE<\/jats:styled-content>\n \/\n DRSP<\/jats:styled-content>\n ) on glucose tolerance in women with polycystic ovary syndrome (\n PCOS<\/jats:styled-content>\n ).\n <\/jats:p>\n <\/jats:sec>\n \n Materials and Methods<\/jats:title>\n \n This open\u2010label, randomised crossover trial was conducted from January 2024 to January 2025. Women with\n PCOS<\/jats:styled-content>\n , diagnosed according to the modified 2003 Rotterdam criteria, received three cycles of either\n E4<\/jats:styled-content>\n 15\u2009mg\/\n DRSP<\/jats:styled-content>\n 3\u2009mg or\n EE<\/jats:styled-content>\n 30\u2009mcg\/\n DRSP<\/jats:styled-content>\n 3\u2009mg. After a 2\u2010month washout, participants crossed over to the alternate regimen for three further cycles. Glucose tolerance (via 75\u2009g oral glucose tolerance test [\n OGTT<\/jats:styled-content>\n ]), insulin levels and homeostatic model assessment for insulin resistance (\n HOMA<\/jats:styled-content>\n \u2010\n IR<\/jats:styled-content>\n ) were compared between treatments.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Of 66 women enrolled, 61 completed both treatment phases. Baseline characteristics were comparable. No significant differences were observed in the mean changes in 2\u2010h\n OGTT<\/jats:styled-content>\n (\n E4<\/jats:styled-content>\n \/\n DRSP<\/jats:styled-content>\n : 4.65\u2009mg\/\n dL<\/jats:styled-content>\n [95% confidence interval (\n CI<\/jats:styled-content>\n ) \u22122.37 to 11.66] vs.\n EE<\/jats:styled-content>\n \/\n DRSP<\/jats:styled-content>\n : 14.40\u2009mg\/\n dL<\/jats:styled-content>\n [95%\n CI<\/jats:styled-content>\n 7.50\u201321.29];\n p<\/jats:italic>\n \u2009=\u20090.05; upper boundary for non\u2010inferiority margin of 14.29), 1\u2010h insulin levels (\u22121.04\u2009\n \u03bcU<\/jats:styled-content>\n \/\n mL<\/jats:styled-content>\n [95%\n CI<\/jats:styled-content>\n \u221225.94 to 23.86] vs. \u22120.77\u2009\n \u03bcU<\/jats:styled-content>\n \/\n mL<\/jats:styled-content>\n [95%\n CI<\/jats:styled-content>\n \u221225.24 to 23.70];\n p<\/jats:italic>\n \u2009=\u20090.99; upper boundary for non\u2010inferiority margin of 50.72) or\n HOMA<\/jats:styled-content>\n \u2010\n IR<\/jats:styled-content>\n (0.28 [95%\n CI<\/jats:styled-content>\n \u22120.24 to 0.80] vs. 0.60 [95%\n CI<\/jats:styled-content>\n 0.09\u20131.11];\n p<\/jats:italic>\n \u2009=\u20090.39; upper boundary for non\u2010inferiority margin of 1.06).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n E4\/DRSP was not inferior to EE\/DRSP in its effects on glucose tolerance, insulin levels and HOMA\u2010IR, supporting its use as a potential oral contraceptive option in women with PCOS.<\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/dom.70126","type":"journal-article","created":{"date-parts":[[2025,9,12]],"date-time":"2025-09-12T08:51:22Z","timestamp":1757667082000},"page":"7244-7257","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Effects of estetrol\/drospirenone versus ethinyl estradiol\/drospirenone on glucose tolerance in women with polycystic ovary syndrome: A randomised controlled trial"],"prefix":"10.1111","volume":"27","author":[{"given":"Phattarika","family":"Bunyapipat","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology, Faculty of Medicine Prince of Songkla University Songkhla Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6843-1216","authenticated-orcid":false,"given":"Satit","family":"Klangsin","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Faculty of Medicine Prince of Songkla University Songkhla Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4263-5226","authenticated-orcid":false,"given":"Krantarat","family":"Peeyananjarassri","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Faculty of Medicine Prince of Songkla University Songkhla Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-2743-2627","authenticated-orcid":false,"given":"Saranya","family":"Wattanakumtornkul","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Faculty of Medicine Prince of Songkla University Songkhla Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sirapat","family":"Katesuwan","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Faculty of Medicine Prince of Songkla University Songkhla Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1219-9814","authenticated-orcid":false,"given":"Alan","family":"Geater","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Faculty of Medicine Prince of Songkla University Songkhla Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amornkan","family":"Numit","sequence":"additional","affiliation":[{"name":"Department of Pathology, Faculty of Medicine Prince of Songkla University Songkhla Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,9,12]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1210\/er.2015\u20101018"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2009\u20102724"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/s1472\u20106483(10)60175\u20107"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMcp1514916"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1210\/edrv.18.6.0318"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1210\/jcem.83.8.5054"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1210\/jcem.84.1.5393"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.22.1.141"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2010.11.036"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2016.11.013"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF03346756"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.contraception.2021.01.001"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/dey256"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1080\/17512433.2017.1271708"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1080\/13625180600983082"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2010\u20102547"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/cen.13112"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2003\u2010031158"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.15585\/mmwr.rr6504a1"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1201\/9781584887409"},{"key":"e_1_2_11_22_1","first-page":"896","volume-title":"Berek & Novak's Gynecology","author":"Peterson KR","year":"2020"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1177\/2168479015608415"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.2165\/11591200\u2010000000000\u201000000"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464\u20105491.2006.01858.x"},{"key":"e_1_2_11_26_1","volume-title":"The Asia\u2010Pacific Perspective: Redefining Obesity and its Treatment","author":"World Health Organization, Regional Office for the Western Pacific (WPRO)","year":"2000"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.20.7.1183"},{"key":"e_1_2_11_28_1","first-page":"394","volume-title":"Speroff's Clinical Gynecologic Endocrinology and Infertility","author":"Taylor HS","year":"2020"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1210\/er.2011\u20101034"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1210\/jcem\u201067\u20103\u2010460"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1080\/17512433.2022.2054413"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijgo.2008.05.017"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365\u20102265.2012.04415.x"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijgo.2015.06.065"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.14310\/horm.2002.1553"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dmt038"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.beem.2012.09.004"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.3109\/13625187.2013.785515"},{"key":"e_1_2_11_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0010\u20107824(02)00537\u20101"},{"key":"e_1_2_11_40_1","doi-asserted-by":"publisher","DOI":"10.1515\/cclm\u20102023\u20100384"},{"key":"e_1_2_11_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.contraception.2022.10.004"},{"key":"e_1_2_11_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.contraception.2024.110727"},{"key":"e_1_2_11_43_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2014\u20103886"}],"container-title":["Diabetes, Obesity and Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dom-pubs.pericles-prod.literatumonline.com\/doi\/pdf\/10.1111\/dom.70126","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/dom-pubs.pericles-prod.literatumonline.com\/doi\/full-xml\/10.1111\/dom.70126","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/dom-pubs.pericles-prod.literatumonline.com\/doi\/pdf\/10.1111\/dom.70126","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,17]],"date-time":"2026-02-17T15:30:12Z","timestamp":1771342212000},"score":1,"resource":{"primary":{"URL":"https:\/\/dom-pubs.pericles-prod.literatumonline.com\/doi\/10.1111\/dom.70126"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9,12]]},"references-count":42,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2025,12]]}},"alternative-id":["10.1111\/dom.70126"],"URL":"https:\/\/doi.org\/10.1111\/dom.70126","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.1111\/DOM.70126\/v2\/review3","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/DOM.70126\/v2\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/DOM.70126\/v1\/review4","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/DOM.70126\/v1\/review3","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/DOM.70126\/v2\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/DOM.70126\/v1\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/DOM.70126\/v1\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/DOM.70126\/v2\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/DOM.70126\/v1\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/DOM.70126\/v2\/decision1","asserted-by":"object"}]},"ISSN":["1462-8902","1463-1326"],"issn-type":[{"value":"1462-8902","type":"print"},{"value":"1463-1326","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,9,12]]},"assertion":[{"value":"2025-06-08","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-09-03","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-09-12","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}