{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T04:42:18Z","timestamp":1790138538363,"version":"4.0.1"},"reference-count":66,"publisher":"Wiley","issue":"S1","license":[{"start":{"date-parts":[[2025,9,29]],"date-time":"2025-09-29T00:00:00Z","timestamp":1759104000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,9,29]],"date-time":"2025-09-29T00:00:00Z","timestamp":1759104000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100016304","name":"Medtronic","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100016304","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["dom-pubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabetes Obesity Metabolism"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>To provide an updated analysis of the performance of different hybrid closed loop (HCL) systems in randomised controlled trials (RCTs) on subjects with type 1 diabetes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and methods<\/jats:title>\n                    <jats:p>We conducted a systematic review with meta\u2010analysis. We searched four online databases and performed hand\u2010searching of conference proceedings to find studies from inception to 18 April 2025. We included RCTs enrolling subjects with type 1 diabetes, evaluating commercial HCL systems against other insulin therapy regimens, with a duration of intervention \u22652\u2009weeks, and reporting time in range (TIR) as an outcome. Studies involving pregnant women were excluded.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 37 studies evaluating seven different HCL systems (CamAPS Fx, Control IQ, DBLG1, iLet BP, MiniMed 670G, MiniMed 780G, and Omnipod 5) were included. In studies with a mean age\u2009&lt;\u200918\u2009years, mean TIR was 64.1% (95% CI: 61\u201067.2), ranging from 59.3% (95% CI: 49.6\u201069.1) with MiniMed 780G to 68% (95% CI: 65.8\u201070.3) with Control IQ, and end\u2010of\u2010study HbA1c was 7.4% (95% CI: 7\u20107.7), ranging from 6.7% (95% CI: 6.6\u20106.9) with CamAPS Fx to 7.9% (95% CI: 6.9\u20109) with MiniMed 780G. In studies with a mean age\u2009\u2265\u200918\u2009years, mean TIR was 70.8% (95% CI: 68.6\u201073), ranging from 63.1% (95% CI: 59.4\u201066.8) with Omnipod 5 to 74.4% (95% CI: 69.7\u201079.1) with MiniMed 780G, and end\u2010of\u2010study HbA1c was 7.1% (95% CI: 7\u20107.3), ranging from 7.0% (95% CI: 6.9\u20107.1) with Control IQ to 7.2% (95% CI: 7\u20107.5) with MiniMed 670G.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In RCTs, commercial HCL systems show different achievements of CGM metrics and HbA1c in people with type 1 diabetes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/dom.70150","type":"journal-article","created":{"date-parts":[[2025,9,30]],"date-time":"2025-09-30T05:15:43Z","timestamp":1759209343000},"page":"3-12","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Glycaemic control and variability with different commercially available hybrid closed loop systems in people with type 1 diabetes: A systematic review and meta\u2010analysis of randomized controlled trials"],"prefix":"10.1111","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3454-7330","authenticated-orcid":false,"given":"Sergio","family":"Di Molfetta","sequence":"first","affiliation":[{"name":"Endocrinology Unit University Hospital \u201cConsorziale Policlinico\u201d of Bari  Bari Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-8165-7531","authenticated-orcid":false,"given":"Ludovico","family":"Di Gioia","sequence":"additional","affiliation":[{"name":"Department of Precision and Regenerative Medicine and Ionian Area, Section of Internal Medicine, Endocrinology, Andrology and Metabolic Diseases University of Bari Aldo Moro  Bari Italy"},{"name":"Endocrinology Unit Regional General Hospital \u201cFrancesco Miulli\u201d  Bari 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