{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T04:43:35Z","timestamp":1785473015723,"version":"3.56.0"},"reference-count":44,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2025,9,29]],"date-time":"2025-09-29T00:00:00Z","timestamp":1759104000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,9,29]],"date-time":"2025-09-29T00:00:00Z","timestamp":1759104000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100005866","name":"Far Eastern Memorial Hospital","doi-asserted-by":"publisher","award":["#FEMH\u20102024\u2010C\u2010057"],"award-info":[{"award-number":["#FEMH\u20102024\u2010C\u2010057"]}],"id":[{"id":"10.13039\/501100005866","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["dom-pubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabetes Obesity Metabolism"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>\n                      To individually evaluate the cardiovascular safety of low\u2010 and high\u2010affinity cardiac mitochondrial ATP\u2010sensitive potassium (mitoK\n                      <jats:sub>ATP<\/jats:sub>\n                      ) channel sulfonylureas by comparing each to dipeptidyl peptidase\u20104 inhibitors (DPP\u20104i), a generally cardiovascular\u2010neutral comparator, given prior evidence suggesting greater cardiovascular risk with high\u2010affinity agents and the absence of a neutral active comparator.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A new user, active comparator cohort study using propensity score\u2010based inverse probability of treatment weighting was conducted with Taiwan's nationwide claims database (2012\u20132022). Patients with recent pre\u2010entry cardiovascular events were excluded. The primary outcome was 3\u2010point major adverse cardiovascular events (MACE: ischaemic stroke, myocardial infarction, cardiovascular death); secondary outcomes included each MACE component and all\u2010cause mortality.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The study cohort included 466\u2009158, 83\u2009031, and 473\u2009539 new users of low\u2010affinity mitoK\n                      <jats:sub>ATP<\/jats:sub>\n                      \u2010channel sulfonylureas (gliclazide, glimepiride), high\u2010affinity sulfonylureas (glyburide, glipizide), and DPP\u20104i, respectively (mean age, 60.2\u2009years; 55.6% male). Compared with DPP\u20104i, low\u2010affinity sulfonylureas were not associated with increased risks of 3\u2010point MACE (Hazard ratio [HR], 1.01; 95% confidence interval [CI], 0.96\u20131.06), cardiovascular death (HR, 1.01; 95% CI, 0.93\u20131.08), or all\u2010cause mortality (HR, 0.97; 95% CI, 0.93\u20131.01). Conversely, high\u2010affinity sulfonylureas were associated with 1.17\u20131.31\u2010fold increased risks of 3\u2010point MACE, cardiovascular death, and all\u2010cause mortality.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      Initiating low\u2010affinity mitoK\n                      <jats:sub>ATP<\/jats:sub>\n                      \u2010channel sulfonylureas demonstrated cardiovascular safety comparable to DPP\u20104i, whereas high\u2010affinity sulfonylureas were linked to increased cardiovascular risk and all\u2010cause mortality. These findings suggest low\u2010affinity sulfonylureas are a safer alternative to high\u2010affinity agents and as safe as DPP\u20104i. They may be appropriate for individuals with diabetes when newer therapies are inaccessible or unnecessary.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/dom.70157","type":"journal-article","created":{"date-parts":[[2025,9,29]],"date-time":"2025-09-29T09:14:19Z","timestamp":1759137259000},"page":"7502-7513","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Comparative cardiovascular risk of sulfonylureas with low\u2010 and high\u2010affinities for cardiac mitochondrial adenosine triphosphate\u2010sensitive potassium channels versus dipeptidyl peptidase\u20104 inhibitors in patients with type 2 diabetes: A cohort study"],"prefix":"10.1111","volume":"27","author":[{"given":"Mei\u2010Hsiu","family":"Chen","sequence":"first","affiliation":[{"name":"Division of Endocrinology, Department of Internal Medicine Far Eastern Memorial Hospital  New Taipei City Taiwan"},{"name":"Department of Biomedical Engineering Ming Chuang University  Taoyuan City Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liang\u2010Yu","family":"Lin","sequence":"additional","affiliation":[{"name":"Faculty of Medicine National Yang Ming Chiao Tung University  Taipei Taiwan"},{"name":"Division of Endocrinology and Metabolism, Department of Medicine Taipei Veterans General Hospital  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tung\u2010Ying","family":"Hung","sequence":"additional","affiliation":[{"name":"Department of Pharmacy National Yang Ming Chiao Tung University  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tzu\u2010Chieh","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Pharmacy National Yang Ming Chiao Tung University  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chia\u2010Yu","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Pharmacy National Yang Ming Chiao Tung University  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tzu\u2010Han","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Pharmacy National Yang Ming Chiao Tung University  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi\u2010Hsuan","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Pharmacy National Yang Ming Chiao Tung University  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4107-0788","authenticated-orcid":false,"given":"Jun\u2010Ting","family":"Liou","sequence":"additional","affiliation":[{"name":"Division of Cardiology China Medical University Hsinchu Hospital  Zhubei City Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2153-6632","authenticated-orcid":false,"given":"Meng\u2010Ting","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Pharmacy National Yang Ming Chiao Tung University  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,9,29]]},"reference":[{"key":"e_1_2_12_2_1","volume-title":"IDF Diabetes Atlas","year":"2025"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-8587(18)30233-X"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.deman.2021.100002"},{"issue":"2","key":"e_1_2_12_5_1","first-page":"28","article-title":"Redefining the therapeutic wheel of diabetes management","volume":"12","author":"Maladkar M","year":"2018","journal-title":"J Cardiol Cardiovasc Ther"},{"key":"e_1_2_12_6_1","first-page":"789","article-title":"A study of the effects of hypoglycemic agents on vascular complications in patients with adult\u2010onset diabetes. 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