{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T06:52:08Z","timestamp":1792047128097,"version":"4.4.0"},"reference-count":126,"publisher":"Wiley","issue":"S1","license":[{"start":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T00:00:00Z","timestamp":1759881600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T00:00:00Z","timestamp":1759881600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100016304","name":"Medtronic","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100016304","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["dom-pubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabetes Obesity Metabolism"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>Automated insulin delivery (AID) is part of the standard of care for type 1 diabetes (T1D), but real\u2010world evidence (RWE) comparing AID systems remains limited. A systematic review and meta\u2010analysis was conducted for outcomes across commercially available AID systems in real\u2010world settings.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>\n                      PubMed and Embase were searched to March 2025 for RWE studies of commercial AID systems in ambulatory people with T1D. Eligible studies had\n                      <jats:italic>n<\/jats:italic>\n                      \u2009\u2265\u2009250 with \u226510\u2009days of continuous glucose monitoring data. Main outcomes were time in range (TIR) and glycated haemoglobin (HbA1c). Random\u2010effects meta\u2010analyses with AID system as moderator were performed, including scenario analyses by age and optimal device settings.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Thirty\u2010six records covering 34 studies with 635\u2009463 users were included. Studies evaluated MiniMed\u2122 780G (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200916), Control\u2010IQ\u2122 (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20099), MiniMed\u2122 670G (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20096), and other systems (\u22643 studies each). Meta\u2010analysis demonstrated frequently statistically significant between\u2010system differences in TIR, ranging from 60.1% (95% confidence interval [CI] 54.0 to 65.9) for Omnipod\u00ae 5 to 73.9% (95% CI 72.3 to 75.5) for MiniMed 780G. For HbA1c, estimates ranged from 6.5% (95% CI 5.4 to 7.7) for Loop to 7.0% (95% CI 6.7 to 7.4) for MiniMed 780G, although differences were not significant. Significant residual heterogeneity was observed. Age was an important effect modifier, with younger users experiencing less favourable outcomes. Optimal device settings improved glycaemic outcomes.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>RWE demonstrated differences in glycaemic outcomes, including TIR, between commercially available AID systems. User age influenced outcomes for all systems. Results must be interpreted cautiously given challenges and potential biases with RWE.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/dom.70161","type":"journal-article","created":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T08:28:39Z","timestamp":1759912119000},"page":"13-34","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["A systematic literature review and meta\u2010analysis of real\u2010world evidence on commercially available automated insulin delivery systems in people with type 1 diabetes"],"prefix":"10.1111","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8065-755X","authenticated-orcid":false,"given":"Johannes","family":"P\u00f6hlmann","sequence":"first","affiliation":[{"name":"Covalence Research  Harpenden 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