{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T18:34:10Z","timestamp":1786646050300,"version":"build-2736575974"},"reference-count":27,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,10,6]],"date-time":"2025-10-06T00:00:00Z","timestamp":1759708800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,10,6]],"date-time":"2025-10-06T00:00:00Z","timestamp":1759708800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100003286","name":"Kuwait Foundation for the Advancement of Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003286","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["dom-pubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabetes Obesity Metabolism"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>\n                      This study aimed to compare the effects of tirzepatide, semaglutide, and liraglutide on body weight and metabolic risk markers over 12\u2009months in people with body mass index \u226527\u2009kg\/m\n                      <jats:sup>2<\/jats:sup>\n                      and type 1 diabetes (T1D).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      This real\u2010world study included 250 people with obesity and T1D (female\u2009=\u200954.8%), treated with either tirzepatide (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200935), semaglutide (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200936), liraglutide (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200997) or usual care (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200982). Secondary outcomes included changes in lipid profile, renal and liver markers, blood pressure, and HbA1c.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      All three agents led to significant weight loss. Tirzepatide showed the greatest reduction of weight loss (10.9%;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001), followed by semaglutide (9.9%;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001) and liraglutide (7.1%;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). Dose\u2010dependent reductions were observed for tirzepatide and semaglutide. Tirzepatide, semaglutide and liraglutide modestly reduced HbA1c by 0.65% (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.004), 0.33% (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.034) and 0.23% (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.017), respectively. LDL\u2010cholesterol was reduced by semaglutide (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.05) and liraglutide (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.02), and liraglutide also lowered the urine albumin\u2010to\u2010creatinine ratio (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.007). There was no change in body weight and HbA1c in the usual care group. No severe hypoglycaemia or diabetic ketoacidosis (DKA) events were reported in any group.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Tirzepatide, semaglutide, and liraglutide reduced bodyweight and improved in selected metabolic risk markers over 12\u2009months without increasing the risk for hypoglycaemia or DKA. Weight loss appeared less compared with patients without diabetes. Tirzepatide, semaglutide and liraglutide modestly improved glycaemic control in adults with T1D and obesity. These findings support the potential adjunctive role of GLP\u20101 receptor agonists in people with obesity and T1D and underscore the need for further validation through randomized controlled trials.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/dom.70172","type":"journal-article","created":{"date-parts":[[2025,10,6]],"date-time":"2025-10-06T09:00:08Z","timestamp":1759741208000},"page":"166-173","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Weight loss in people with type 1 diabetes over 12\u2009months: Real\u2010world data comparing tirzepatide, semaglutide and liraglutide"],"prefix":"10.1111","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5006-4369","authenticated-orcid":false,"given":"Ebaa","family":"Al Ozairi","sequence":"first","affiliation":[{"name":"DAFNE Unit, Clinical Care Research and Clinical Trials Unit Dasman Diabetes Institute  Kuwait City Kuwait"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7520-0221","authenticated-orcid":false,"given":"Mohammad","family":"Irshad","sequence":"additional","affiliation":[{"name":"DAFNE Unit, Clinical Care Research and Clinical Trials Unit Dasman Diabetes Institute  Kuwait City Kuwait"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jumana","family":"Alkandari","sequence":"additional","affiliation":[{"name":"DAFNE Unit, Clinical Care Research and Clinical Trials Unit Dasman Diabetes Institute  Kuwait City Kuwait"},{"name":"Amiri Hospital, Ministry of Health  Kuwait City Kuwait"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Litty","family":"Sojan","sequence":"additional","affiliation":[{"name":"DAFNE Unit, Clinical Care Research and Clinical Trials Unit Dasman Diabetes Institute  Kuwait City 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