{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T12:41:08Z","timestamp":1784551268328,"version":"3.55.0"},"reference-count":37,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,10,14]],"date-time":"2025-10-14T00:00:00Z","timestamp":1760400000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,10,14]],"date-time":"2025-10-14T00:00:00Z","timestamp":1760400000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100004339","name":"Sanofi","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004339","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["dom-pubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabetes Obesity Metabolism"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>To compare the efficacy and safety of insulin glargine 100\u2009U\/mL plus lixisenatide (iGlarLixi) with insulin degludec plus insulin aspart (IDegAsp) by \u03b2\u2010cell function in exploratory analyses of the Soli\u2010D study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>Soli\u2010D was a 24\u2010week, multicentre, randomised, open\u2010label study in Chinese adults with uncontrolled type 2 diabetes (T2D) on oral antidiabetic drugs (OADs). We evaluated glycaemic efficacy, body weight, total insulin daily dose and hypoglycaemia outcomes with iGlarLixi versus IDegAsp by baseline fasting C\u2010peptide and Homeostasis Model Assessment of \u03b2\u2010cell function (HOMA\u2010\u03b2) quartile measurements.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Among 386 participants, change in glycated haemoglobin (HbA1c), fasting plasma glucose or postprandial glucose at Week 24 showed no interaction with fasting C\u2010peptide or HOMA\u2010\u03b2 quartile. The difference in HbA1c change favoured iGlarLixi versus IDegAsp in fasting C\u2010peptide quartile 1 (Q1;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.045) and Q2 (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.023) and HOMA\u2010\u03b2 Q1 (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.025). The proportion of participants with HbA1c &lt;7.0% (&lt;53\u2009mmol\/mol) was higher with iGlarLixi in fasting C\u2010peptide Q2 (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.009) and HOMA\u2010\u03b2 Q1 (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.013). Body weight benefits were observed with iGlarLixi in HOMA\u2010\u03b2 Q1 (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.003). Total insulin daily dose was lower with iGlarLixi, showing interactions between C\u2010peptide or HOMA\u2010\u03b2 quartile and insulin dose (U or U\/kg;\n                      <jats:italic>p<\/jats:italic>\n                      <jats:sub>int<\/jats:sub>\n                      \u2009&lt;0.001 for all). The event rate for any hypoglycaemia and American Diabetes Association Level 1 hypoglycaemia was lower with iGlarLixi in HOMA\u2010\u03b2 Q1 (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.040 and 0.037).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>iGlarLixi provides improved glycaemic control at lower insulin daily doses compared with IDegAsp, regardless of C\u2010peptide or HOMA\u2010\u03b2 levels, in Chinese people with uncontrolled T2D on OADs.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/dom.70181","type":"journal-article","created":{"date-parts":[[2025,10,14]],"date-time":"2025-10-14T12:27:38Z","timestamp":1760444858000},"page":"242-255","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Efficacy and safety of\n                    <scp>iGlarLixi<\/scp>\n                    versus\n                    <scp>IDegAsp<\/scp>\n                    by baseline \u03b2\u2010cell function in Chinese people with type 2 diabetes: Exploratory analyses of the Soli\u2010D study"],"prefix":"10.1111","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8690-645X","authenticated-orcid":false,"given":"Weijun","family":"Gu","sequence":"first","affiliation":[{"name":"Department of Endocrinology, First Medical Center Chinese People's Liberation Army General Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5984-3342","authenticated-orcid":false,"given":"Xiaohong","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Endocrinology Zhejiang Provincial People's Hospital (Affiliated People's Hospital, Hangzhou Medical College)  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minlu","family":"Zhang","sequence":"additional","affiliation":[{"name":"Sanofi  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyi","family":"Wang","sequence":"additional","affiliation":[{"name":"Sanofi  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qin","family":"Du","sequence":"additional","affiliation":[{"name":"Sanofi  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Kang","sequence":"additional","affiliation":[{"name":"Sanofi  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felipe","family":"Lauand","sequence":"additional","affiliation":[{"name":"Sanofi  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agustina","family":"Alvarez","sequence":"additional","affiliation":[{"name":"Sanofi  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3344-3540","authenticated-orcid":false,"given":"Yiming","family":"Mu","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, First Medical Center Chinese People's Liberation Army General Hospital  Beijing 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