{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T15:06:35Z","timestamp":1785855995503,"version":"3.56.0"},"reference-count":31,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T00:00:00Z","timestamp":1761091200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T00:00:00Z","timestamp":1761091200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["JP17dk0207038"],"award-info":[{"award-number":["JP17dk0207038"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["dom-pubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabetes Obesity Metabolism"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>Certain antidiabetic agents may prevent dementia in patients with type 2 diabetes mellitus (T2DM). The purpose of this study is to elucidate the relative effect of antidiabetic agents on reducing dementia risk in patients with T2DM.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>PubMed, Cochrane Library and Igaku Chuo Zasshi\u2010Web from inception to 31 December 2023 were searched. Trials reported in English or Japanese language that assessed the effects of glucose\u2010lowering drugs on dementia were selected.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Overall, 67 trials (4\u2009088\u2009683 individuals) assessing nine antidiabetic agent classes were included. Studies comprised monotherapies versus control (no use of antidiabetic agents or placebo) (three trials), monotherapies versus add\u2010on therapies (one trial) and real\u2010world database studies (63 trials). The analysis showed that the risk of dementia decreased with sodium\u2010glucose cotransporter 2 inhibitors (SGLT2i), glucagon\u2010like peptide\u20101 receptor agonists (GLP1\u2010RA), thiazolidinediones (TZD) and dipeptidyl peptidase\u20104 inhibitors (DPP4i) compared with the reference (placebo, no use of antidiabetic agents or other antidiabetic agents). Conversely, insulin was associated with an increased risk of dementia, whereas no significant association was found with the use of metformin, sulfonylureas, glinides and \u03b1\u2010glucosidase inhibitors. Analyses of treatment rankings further revealed the relative effect on reducing dementia risk in the following order: SGLT2i\u2009&gt;\u2009GLP1\u2010RA\u2009&gt;\u2009TZD\u2009&gt;\u2009DPP4i; insulin ranked the lowest.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The most effective antidiabetic agent in reducing dementia risk in T2DM is SGLT2i, followed by GLP1\u2010RA, TZD and DPP4i, whereas insulin is associated with an elevated risk of dementia.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/dom.70182","type":"journal-article","created":{"date-parts":[[2025,10,23]],"date-time":"2025-10-23T06:10:45Z","timestamp":1761199845000},"page":"256-264","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Antidiabetic agents and dementia risk in type 2 diabetes: A systematic review and network meta\u2010analysis"],"prefix":"10.1111","volume":"28","author":[{"given":"Sayaka","family":"Kato","sequence":"first","affiliation":[{"name":"Department of Endocrinology, Metabolism, and Hypertension Research Clinical Research Institute, NHO Kyoto Medical Center  Kyoto Japan"},{"name":"Department of Endocrinology and Metabolism, Graduate School of Medical Science Kyoto Prefectural University of Medicine  Kyoto Japan"},{"name":"Department of Metabolism and Endocrinology Japanese Red Cross Kyoto Daini Hospital  Kyoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-8790-587X","authenticated-orcid":false,"given":"Naoki","family":"Ozu","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Metabolism, and Hypertension Research Clinical Research Institute, NHO Kyoto Medical Center  Kyoto Japan"},{"name":"Institute for Clinical and Translational Science Nara Medical University Hospital  Nara 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Metabolism, and Hypertension Research Clinical Research Institute, NHO Kyoto Medical Center  Kyoto Japan"},{"name":"Department of Metabolic Research, Geroscience Research Center, Research Institute National Center for Geriatrics and Gerontology  Aichi Japan"},{"name":"Department of Rehabilitation Health Science University  Yamanashi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michiaki","family":"Fukui","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism, Graduate School of Medical Science Kyoto Prefectural University of Medicine  Kyoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mitsuhiko","family":"Noda","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Diabetes Saitama Medical University  Saitama Japan"},{"name":"Department of Diabetes, Metabolism and Endocrinology Ichikawa Hospital, International University of Health and Welfare  Chiba 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