{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T19:39:57Z","timestamp":1772998797534,"version":"3.50.1"},"reference-count":34,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,10,14]],"date-time":"2025-10-14T00:00:00Z","timestamp":1760400000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,10,14]],"date-time":"2025-10-14T00:00:00Z","timestamp":1760400000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["dom-pubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabetes Obesity Metabolism"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>Although Type 1 diabetes mellitus (T1D) can be managed by insulin injections and dietary regulation, it is unclear whether dietary intervention following the onset of T1D can reverse its pathology. This study aimed to explore the effects of Fibre\u2010N, a sucrose removed sugarcane extract, on glycemic control, insulin requirements, pancreatic structure and function, as well as local and systemic inflammation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and methods<\/jats:title>\n                    <jats:p>8\u2010week\u2010old male eNOS\u2010\/\u2010 mice were injected with Streptozotocin (STZ) for 5 consecutive days to induce T1D, followed by either standard chow (D), Fibre\u2010N (D+N) or a control fibre, Maltodextrin (D+M) for 24\u2009weeks.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The results showed that T1D led to significant reductions in body and pancreatic weight compared to healthy animals. This was associated with hyperglycemia, significant loss in islet and \u03b2\u2010cell numberFibre\u2010N reduced blood glucose level and the insulin requirements in T1D mice, while improving pancreatic morphology, insulin expression and blood C\u2010peptide levels. On the other hand, Maltodextrin showed no significant effects. T1D was also associated with increased expression of oxidative stress, fibrotic and inflammatory markers in the pancreas, which was partially reversed by Fibre\u2010N. In addition, the diet also suppressed multiple inflammatory markers in the blood as well as improving the gut microbiota balance.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This supports the role of Fibre\u2010N in improving glucose control in mice with T1D via the gut\u2010pancreas axis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/dom.70183","type":"journal-article","created":{"date-parts":[[2025,10,14]],"date-time":"2025-10-14T12:21:53Z","timestamp":1760444513000},"page":"265-274","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The effect of sugarcane extract supplementation on glycemic control in a mouse model of type 1 diabetes"],"prefix":"10.1111","volume":"28","author":[{"given":"Amgad","family":"Zaky","sequence":"first","affiliation":[{"name":"Renal Research Laboratory, Kolling Institute of Medical Research University of Sydney  Sydney New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0630-4959","authenticated-orcid":false,"given":"Long The","family":"Nguyen","sequence":"additional","affiliation":[{"name":"Renal Research Laboratory, Kolling Institute of Medical Research University of Sydney  Sydney New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ying","family":"Shi","sequence":"additional","affiliation":[{"name":"Renal Research Laboratory, Kolling Institute of Medical Research University of Sydney  Sydney New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miao","family":"Hou","sequence":"additional","affiliation":[{"name":"Children's Hospital of Soochow University  Jiangsu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hasinika K. 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