{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T05:58:37Z","timestamp":1791266317350,"version":"4.1.0"},"reference-count":56,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T00:00:00Z","timestamp":1760054400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T00:00:00Z","timestamp":1760054400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001648","name":"European Foundation for the Study of Diabetes","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001648","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["dom-pubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabetes Obesity Metabolism"],"published-print":{"date-parts":[[2026,1]]},"abstract":"Abstract<\/jats:title>\n \n Aims<\/jats:title>\n The incretin hormones glucose\u2010dependent insulinotropic polypeptide (GIP) and glucagon\u2010like peptide 1 (GLP\u20101) influence metabolism through strong effects on pancreatic hormone secretion but also in a pancreas\u2010independent manner. Here, we investigated the isolated extrapancreatic effects of endogenous GIP and GLP\u20101 by applying hormone receptor antagonists in totally pancreatectomized individuals.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n Twelve totally pancreatectomized individuals each underwent four 270\u2010min liquid mixed meal tests (480\u2009kcal) in a randomized study design with infusions of the GIP receptor antagonist GIP(3\u201030)NH\n 2<\/jats:sub>\n (800\u2009pmol\/kg\/min), the GLP\u20101 receptor antagonist exendin(9\u201039)NH\n 2<\/jats:sub>\n (450\u2009pmol\/kg\/min), GIP(3\u201030)NH\n 2<\/jats:sub>\n \u2009+\u2009exendin(9\u201039)NH\n 2<\/jats:sub>\n , and saline (placebo), respectively. Blood samples, appetite\u2010related measures, heart rate, blood pressure, and\n ad libitum<\/jats:italic>\n food intake data were collected. Participants continued their basal insulin but omitted bolus insulin in the morning of the experiment.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Infusions of GIP(3\u201030)NH\n 2<\/jats:sub>\n and GIP(3\u201030)NH\n 2<\/jats:sub>\n \u2009+\u2009exendin(9\u201039)NH\n 2<\/jats:sub>\n attenuated meal\u2010induced inhibition of bone resorption (carboxy\u2010terminal collagen crosslinks) (nadir [mean\u2009\u00b1\u2009SD] to 84\u2009\u00b1\u20099% and to 85\u2009\u00b1\u20098% of baseline, compared to placebo (64\u2009\u00b1\u200915%) (\n p<\/jats:italic>\n s\u2009<0.05)). During exendin(9\u201039)NH\n 2<\/jats:sub>\n and exendin(9\u201039)NH\n 2<\/jats:sub>\n \u2009+\u2009GIP(3\u201030)NH\n 2<\/jats:sub>\n co\u2010infusion, GLP\u20101 plasma responses increased (\n p<\/jats:italic>\n s\u2009<0.05). Infusion of GIP(3\u201030)NH\n 2<\/jats:sub>\n or exendin(9\u201039)NH\n 2<\/jats:sub>\n did not affect other measurements.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n Endogenous GIP contributes to the regulation of postprandial bone resorption independently of pancreatic factors. In contrast, GIP receptor and\/or GLP\u20101 receptor antagonism had no measurable effects on glucose metabolism, gastric emptying, appetite, food intake, triglycerides, or haemodynamics, supporting a pancreatic contribution to some of these effects of the endogenous hormones, although the surgical reconstruction may have influenced the sensitivity of the targets.<\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/dom.70186","type":"journal-article","created":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T08:24:01Z","timestamp":1760084641000},"page":"275-286","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Acute effects of\n GIP<\/scp>\n and\n GLP<\/scp>\n \u20101 receptor antagonism in totally pancreatectomized individuals: A randomized double\u2010blind, placebo\u2010controlled crossover study"],"prefix":"10.1111","volume":"28","author":[{"given":"Liva S. L.","family":"Krogh","sequence":"first","affiliation":[{"name":"Center for Clinical Metabolic Research, Gentofte Hospital University of Copenhagen Hellerup Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mads M.","family":"Helsted","sequence":"additional","affiliation":[{"name":"Center for Clinical Metabolic Research, Gentofte Hospital University of Copenhagen Hellerup Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anders","family":"Englund","sequence":"additional","affiliation":[{"name":"Center for Clinical Metabolic Research, Gentofte Hospital University of Copenhagen Hellerup Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natasha C.","family":"Bergmann","sequence":"additional","affiliation":[{"name":"Center for Clinical Metabolic Research, Gentofte Hospital University of Copenhagen Hellerup Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kirsa","family":"Skov\u2010Jeppesen","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences, Faculty of Health and Medical Sciences University of Copenhagen Copenhagen Denmark"},{"name":"Novo Nordisk Foundation Center for Basic Metabolic Research University of Copenhagen Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Casper K.","family":"Nielsen","sequence":"additional","affiliation":[{"name":"Center for Clinical Metabolic Research, Gentofte Hospital University of Copenhagen Hellerup Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carsten P.","family":"Hansen","sequence":"additional","affiliation":[{"name":"Department of Surgery and Transplantation, Rigshospitalet Copenhagen University Hospital Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mette M.","family":"Rosenkilde","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences, Faculty of Health and Medical Sciences University of Copenhagen Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bolette","family":"Hartmann","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences, Faculty of Health and Medical Sciences University of Copenhagen Copenhagen Denmark"},{"name":"Novo Nordisk Foundation Center for Basic Metabolic Research University of Copenhagen Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6853-3805","authenticated-orcid":false,"given":"Jens J.","family":"Holst","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences, Faculty of Health and Medical Sciences University of Copenhagen Copenhagen Denmark"},{"name":"Novo Nordisk Foundation Center for Basic Metabolic Research University of Copenhagen Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Filip K.","family":"Knop","sequence":"additional","affiliation":[{"name":"Center for Clinical Metabolic Research, Gentofte Hospital University of Copenhagen Hellerup Denmark"},{"name":"Novo Nordisk A\/S Bagsv\u00e6rd Denmark"},{"name":"Department of Clinical Medicine, Faculty of Health and Medical Sciences University of Copenhagen Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asger B.","family":"Lund","sequence":"additional","affiliation":[{"name":"Center for Clinical Metabolic Research, Gentofte Hospital University of Copenhagen Hellerup Denmark"},{"name":"Department of Clinical Medicine, Faculty of Health and Medical Sciences University of Copenhagen Copenhagen Denmark"},{"name":"Clinical Research, Steno Diabetes Center Copenhagen University of Copenhagen Herlev 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