{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T00:46:30Z","timestamp":1778805990473,"version":"3.51.4"},"reference-count":24,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T00:00:00Z","timestamp":1760054400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T00:00:00Z","timestamp":1760054400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["dom-pubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabetes Obesity Metabolism"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>While discontinuation of glucagon\u2010like peptide\u20101 receptor agonists (GLP\u20101RAs) before esophagogastroduodenoscopy (EGD) is not universally mandated, safety concerns persist. Evidence remains insufficient for managing specific patient subgroups, particularly in Asian populations. We aimed to provide evidence for stratified risk assessment in a large Japanese cohort.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>\n                      This nationwide retrospective cohort study used the Japan Medical Data Center database. We performed 1:4 propensity score matching based on age, sex, insulin use, HbA1c level, chronic respiratory disease, and body mass index to compare patients with diabetes receiving GLP\u20101RAs (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20093568) with non\u2010users (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200914\u2009246). Respiratory and severe complications within 14\u2009days post\u2010EGD were assessed via logistic regression.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      GLP\u20101RA was not associated with an increased risk of overall (0.39% vs. 0.50%; odds ratio [OR] 0.79, 95% confidence interval [CI] 0.44\u20131.40;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.41) or severe (0.11% vs. 0.077%; 1.45, 0.46\u20134.56;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.52) respiratory complications. While no subgroup analysis reached statistical significance, numerical trends towards a higher risk were observed in new users (OR 1.43; 95% CI, 0.51\u20133.98) and patients with severe diabetes (OR 1.28; 95% CI, 0.64\u20132.52).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>GLP\u20101RA was not associated with increased post\u2010EGD respiratory complications, suggesting that routine discontinuation may be unnecessary for many stable, long\u2010term users. However, our findings do not support a uniform conclusion of safety for all subgroups. The non\u2010significant trends in new users and patients with severe diabetes warrant a cautious, individualised approach for these potentially vulnerable populations. Further research is needed to definitively clarify this risk.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/dom.70194","type":"journal-article","created":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T08:20:13Z","timestamp":1760084413000},"page":"316-323","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Glucagon\u2010like peptide\u20101 receptor agonist and respiratory complications after endoscopy: A Japanese nationwide cohort study"],"prefix":"10.1111","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6184-2215","authenticated-orcid":false,"given":"Hiroyuki","family":"Hisada","sequence":"first","affiliation":[{"name":"Department of Gastroenterology, Graduate School of Medicine The University of Tokyo  Tokyo Japan"},{"name":"Department of Endoscopy and Endoscopic Surgery, Graduate School of Medicine The University of Tokyo  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuhiko","family":"Ikeuchi","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Graduate School of Medicine The University of Tokyo  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yosuke","family":"Tsuji","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Graduate School of Medicine The University of Tokyo  Tokyo Japan"},{"name":"Next\u2010Generation Endoscopic Computer Vision, Graduate School of Medicine The University of Tokyo  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nobutake","family":"Yamamichi","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Graduate School of Medicine The University of Tokyo  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naomi","family":"Kakushima","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Graduate School of Medicine The University of Tokyo  Tokyo Japan"},{"name":"Department of Endoscopy and Endoscopic Surgery, Graduate School of Medicine The University of Tokyo  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuya","family":"Okushin","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Graduate School of Medicine The University of Tokyo  Tokyo Japan"},{"name":"Department of Infection Control and Prevention, Graduate School of Medicine The University of Tokyo  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seiichi","family":"Yakabi","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Graduate School of Medicine The University of Tokyo  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chihiro","family":"Takeuchi","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Graduate School of 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