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Triple oral therapy with metformin, dipeptidyl peptidase\u20104 inhibitors (DPP\u20104i), and sodium\u2010glucose cotransporter\u20102 inhibitors (SGLT2i) has demonstrated high and durable glycaemic\u2010lowering efficacy, favourable safety and tolerability, and additional metabolic benefits in T2DM patients with diverse background therapies, including those who are treatment\u2010na\u00efve and those with inadequate control on monotherapy or dual therapy. In light of the increasing clinical use of this triple regimen and the absence of established consensus to guide its use, the Diabetes Committee of the Chinese Research Hospital Association convened an expert panel comprising endocrinologists and evidence\u2010based experts. Through a systematic literature review and a Delphi process, the panel formulated 11 consensus recommendations (8 strong and 3 weak recommendations) on the clinical use of metformin\u2009+\u2009DPP\u20104i +\u2009SGLT2i, including fixed\u2010dose combination formulations. Safety considerations regarding its use were also described. This consensus aimed to provide clinicians with practical guidance to optimize the effective and safe use of metformin\u2009+\u2009DPP\u20104i +\u2009SGLT2i in T2DM management.<\/jats:p>","DOI":"10.1111\/dom.70197","type":"journal-article","created":{"date-parts":[[2025,10,14]],"date-time":"2025-10-14T12:31:25Z","timestamp":1760445085000},"page":"3-17","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Triple oral therapy with metformin,\n                    <scp>DPP<\/scp>\n                    \u20104 inhibitor, and\n                    <scp>SGLT2<\/scp>\n                    inhibitor for adults with type 2 diabetes: Consensus recommendations of a Chinese expert panel (version 2025)"],"prefix":"10.1111","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1450-9011","authenticated-orcid":false,"given":"Miao","family":"Yu","sequence":"first","affiliation":[{"name":"Department of Endocrinology, Key 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