{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T15:22:04Z","timestamp":1790695324375,"version":"4.1.0"},"reference-count":36,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T00:00:00Z","timestamp":1761609600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T00:00:00Z","timestamp":1761609600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["dom-pubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabetes Obesity Metabolism"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>Acquired hypothalamic obesity (aHO) following craniopharyngioma (CP) is a challenging condition with limited therapeutic options. This study aimed to assess the real\u2010world effectiveness and safety of GLP\u20101 RAs in this population.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>CranioGLP1 is a retrospective multicentre study including 116 adults with aHO treated with one or more GLP\u20101 RAs across 16 French obesity centres. Demographic, clinical, and therapeutic data were collected from medical records. Weight outcomes, adverse events, and predictors of response were analysed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Patients had a mean age of 44.4 \u00b1\u200913.5\u2009years and a mean BMI of 40.1\u2009\u00b1\u20098.6 kg\/m\n                      <jats:sup>2<\/jats:sup>\n                      , 42% had type 2 diabetes. Over a mean follow\u2010up of 44 months, mean weight loss was \u22124.6% (\u00b112.5), with high interindividual variability; 51% achieved \u22655% weight loss, and 28% \u226510%. Semaglutide (mean dose 1.2 mg\/week) was associated with the greatest reduction (\u22126.8%), particularly in patients without diabetes (\u22128.5%\u2009\u00b1\u200912.3 vs. \u22123.9%\u2009\u00b1\u200910.0 in those with diabetes;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.032). Endocrine adverse events occurred in 12% and 10% of patients with adrenal or vasopressin deficiency decompensation, respectively, with 8% requiring hospitalisation. Gastrointestinal intolerance led to treatment discontinuation in 13% of cases.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>GLP\u20101 RAs at submaximal doses induce moderate, yet clinically meaningful weight loss in adults with aHO, with semaglutide showing the highest efficacy. Given the non\u2010negligible risk of hormonal decompensation, specific endocrine monitoring is essential.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/dom.70216","type":"journal-article","created":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T04:44:55Z","timestamp":1761713095000},"page":"443-451","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Effectiveness and safety of\n                    <scp>GLP<\/scp>\n                    \u20101 receptor agonists in craniopharyngioma patients with obesity: A multicentre real\u2010world study"],"prefix":"10.1111","volume":"28","author":[{"given":"Flora","family":"Lambert","sequence":"first","affiliation":[{"name":"Nutrition Department, Reference Center for Rare Diseases PRADORT Assistance Publique\u2014H\u00f4pitaux de Paris, Piti\u00e9\u2010Salp\u00eatri\u00e8re Hospital  Paris 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