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Outcomes included composite renal outcome, estimated glomerular filtration rate (eGFR), and urinary albumin\u2010to\u2010creatinine ratio (UACR). A network meta\u2010analysis was conducted, and the certainty of evidence was assessed with the Grading of Recommendations Assessment, Development, and Evaluation used to evaluate evidence certainty (GRADE).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Twenty RCTs enrolling 80,670 participants were included. Compared with placebo, several agents significantly reduced composite renal outcomes, with dapagliflozin 10\u2009mg showing the greatest efficacy (OR 0.55, 95% CI 0.42\u20130.72; high\u2010certainty evidence), followed by canagliflozin, empagliflozin, efpeglenatide, sotagliflozin 400\u2009mg, semaglutide, and dulaglutide 1.5\u2009mg. Canagliflozin 100\u2013300\u2009mg significantly reduced UACR, whereas dapagliflozin had no effect. None of the novel antidiabetic agents significantly altered eGFR. Certainty of evidence ranged from high for placebo\u2010controlled comparisons to low or very low for indirect estimates.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In patients with T2DM and CKD, SGLT2 inhibitors provide the most consistent renal protection, while GLP\u20101 receptor agonists offer additional but variable benefits. Dapagliflozin showed the greatest efficacy, and canagliflozin most strongly reduced albuminuria, highlighting meaningful heterogeneity across agents. DPP\u20104 inhibitors conferred no renal benefit. Overall, evidence from placebo\u2010controlled trials was robust, whereas certainty was lower for indirect estimates, highlighting the need for drug\u2010specific evaluation in clinical practice.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/dom.70224","type":"journal-article","created":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T13:56:58Z","timestamp":1761659818000},"page":"518-528","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Comparison of the renal outcomes of novel antidiabetic agents in patients with type 2 diabetes with chronic kidney disease: A systematic review and network meta\u2010analysis of randomized controlled trials"],"prefix":"10.1111","volume":"28","author":[{"given":"Rong","family":"Lin","sequence":"first","affiliation":[{"name":"Department of Internal Medicine Far Eastern Memorial Hospital  New Taipei City 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