{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T13:31:49Z","timestamp":1783431109238,"version":"3.54.6"},"reference-count":36,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,11,5]],"date-time":"2025-11-05T00:00:00Z","timestamp":1762300800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,11,5]],"date-time":"2025-11-05T00:00:00Z","timestamp":1762300800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["dom-pubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabetes Obesity Metabolism"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>To evaluate the effectiveness and safety of a hybrid closed\u2010loop (HCL) insulin infusion system in treating adult and adolescent patients with type 1 diabetes (T1D).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>A total of 126 participants (22 adolescents and 104 adults) underwent a 2\u2010week initial treatment phase followed by a 2\u2010week run\u2010in phase with the Equil\u00ae S HCL insulin pump system MTM\u2010Z in Manual Mode with calibration\u2010free continuous glucose monitoring (CGM) System G7, followed by a 12\u2010week study phase with HCL Auto Mode enabled. The primary outcome was the overall mean change in CGM time in range (TIR; 70\u2013180\u2009mg\/dL). Safety endpoints included rates of severe hypoglycaemia, hyperglycaemia and diabetic ketoacidosis (DKA).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Compared with the baseline run\u2010in, Auto Mode increased TIR from 69.11% to 76.72% (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001) and reduced time below range (&lt;70\u2009mg\/dL) from 3.92% to 2.73% (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). The mean sensor glucose (SG) decreased from 151\u2009\u00b1\u200928 to 144 \u00b1\u200919\u2009mg\/dL. The proportion of achieving TIR of &gt;70% increased from 56.03% to 77.59%. The standard deviation (SD: \u22125.90\u2009mg\/dL) and coefficient of variation (CV: \u22122.49%) reduced significantly. The greatest change in TIR (mean 20.55%), mean SG (estimated treatment difference [ETD]: \u221230.13, 95% confidence interval [CI]: \u221241.84, \u221218.41;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.001) and SD of SG (ETD: \u221214.21, 95% CI: \u221221.17, \u22126.71;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.004) was observed in participants with a baseline glycosylated haemoglobin A1c (HbA1c) value of &gt;8.0%. The percentage of achieving combined recommendations for time at SG ranges increased from 25.86% to 56.90%. No severe hypoglycaemia, DKA or adverse events were observed.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>HCL therapy is safe in Chinese adolescent and adult patients with T1D. The 12\u2010week application of the Equil\u00ae S HCL insulin pump system MTM\u2010Z with Auto Mode increased TIR and reduced HbA1c, hyperglycaemia and hypoglycaemia.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/dom.70227","type":"journal-article","created":{"date-parts":[[2025,11,5]],"date-time":"2025-11-05T09:32:34Z","timestamp":1762335154000},"page":"539-550","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Safety and efficacy of hybrid closed\u2010loop insulin pump therapy in adolescents and adults with type 1 diabetes in China"],"prefix":"10.1111","volume":"28","author":[{"given":"Jing","family":"Shen","sequence":"first","affiliation":[{"name":"Department of Endocrinology The Eighth Medical Center of PLA General Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianshu","family":"Zeng","sequence":"additional","affiliation":[{"name":"Department of 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