{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T22:16:59Z","timestamp":1790806619526,"version":"4.1.0"},"reference-count":36,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T00:00:00Z","timestamp":1761523200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T00:00:00Z","timestamp":1761523200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100016304","name":"Medtronic","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100016304","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["dom-pubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabetes Obesity Metabolism"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>This study evaluated 1\u2010year real\u2010world changes in glycaemic management, parent\u2010reported outcomes and safety with an automated insulin delivery (AID) system in young children with type 1 diabetes (T1D).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>Children aged 2\u20136\u2009years whose parents agreed to initiate the Medtronic MiniMed\u2122 780G were enrolled at 15 centres between October 2022 and December 2023. Data were collected quarterly over 1\u2009year during routine follow\u2010up. Parent\u2010reported outcomes were assessed using questionnaires (HAPPI\u2010D\u00a0[part of the HAPPI\u2010D Protocol; Hvid\u00f8re, Adolescent, Parent, Professional, Instrument, Diabetes]\u00a0and Hypoglycaemia Fear Survey [HFS]\u2010Parent). The primary endpoint was the evolution of time in range (TIR, 70\u2013180\u2009mg\/dL) from start to 12\u2009months after start. Data are reported as mean\u2009\u00b1\u2009SD or least\u2010squares mean (95% confidence interval).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 149 children were included (mean age 4.2\u2009\u00b1\u20091.4\u2009years; 56.4% girls). Mean T1D duration was 22.0\u2009\u00b1\u200913.0\u2009months and 75.2% used an insulin pump before. After 1\u2009year, TIR increased from 56.8% (54.4\u201359.2) to 66.6% (64.7\u201368.5) and haemoglobin A1c decreased from 7.6% (7.4\u20137.8) to 7.2% (7.1\u20137.4) (all\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). Time &lt;70\u2009mg\/dL remained stable (5.0% [4.2\u20135.8] at start vs. 4.6% [3.9\u20135.3] at 12\u2009months,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.172). Parents reported less diabetes burden on the HAPPI\u2010D (22.9 points [21.7\u201324.0] at start vs. 21.7 points [20.5\u201322.8] at 12\u2009months,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.001), while scores on the HFS\u2010Parent did not change significantly. There were no hospitalisations for severe hypoglycaemic events and one for diabetic ketoacidosis due to infusion set occlusion.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>One\u2010year use of an AID system in young children with T1D was safe and associated with improved glycaemic management and reduced parental burden, with limited impact on time in hypoglycaemia and related parental fear.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/dom.70228","type":"journal-article","created":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T04:19:59Z","timestamp":1761625199000},"page":"551-561","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["One\u2010year effectiveness and safety in young children aged 2\u20136\u2009years with type 1 diabetes using an automated insulin delivery system: A real\u2010world prospective cohort study"],"prefix":"10.1111","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6007-6715","authenticated-orcid":false,"given":"Jolien","family":"De Meulemeester","sequence":"first","affiliation":[{"name":"Department of Endocrinology University Hospitals Leuven\u2014Department of Clinical and Experimental Endocrinology, KU Leuven  Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-2501-6554","authenticated-orcid":false,"given":"Laura","family":"Valgaerts","sequence":"additional","affiliation":[{"name":"Department of Endocrinology University Hospitals Leuven\u2014Department of Clinical and Experimental Endocrinology, KU Leuven  Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sylvie","family":"Tenoutasse","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Diabetology H\u00f4pital Universitaire de Bruxelles (HUB), H\u00f4pital Universitaire des Enfants Reine Fabiola (HUDERF)  Brussels Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Inge","family":"Gies","sequence":"additional","affiliation":[{"name":"Department of Paediatrics Universitair Ziekenhuis Brussel  Brussels Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marieke","family":"den Brinker","sequence":"additional","affiliation":[{"name":"Department of Paediatric Endocrinology &amp; Diabetology University Hospital Antwerp\u2014Lab of Experimental Medicine and Paediatrics, University of Antwerp  Edegem Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie","family":"Fudvoye","sequence":"additional","affiliation":[{"name":"Department of Paediatrics University Hospital of Li\u00e8ge  Li\u00e8ge Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thierry","family":"Mouraux","sequence":"additional","affiliation":[{"name":"Department of Paediatric Endocrinology University Hospital Center UCL Namur  Yvoir Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacques","family":"Louis","sequence":"additional","affiliation":[{"name":"Department of Paediatrics Grand H\u00f4pital de Charleroi  Charleroi Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophie","family":"Lambert","sequence":"additional","affiliation":[{"name":"Department of Paediatric Endocrinology Clinique CHC Montl\u00e9gia  Li\u00e8ge Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marlies","family":"Van Loocke","sequence":"additional","affiliation":[{"name":"Department of Paediatrics AZ Delta  Roeselare Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Goele","family":"Smeets","sequence":"additional","affiliation":[{"name":"Department of Paediatric Endocrinology Jessa Hospital  Hasselt Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annelies","family":"Lemay","sequence":"additional","affiliation":[{"name":"Department of Paediatrics AZ Turnhout  Turnhout Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sofie","family":"Ryckx","sequence":"additional","affiliation":[{"name":"Department of Paediatrics ZAS Paola  Antwerpen Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sylvia","family":"Depoorter","sequence":"additional","affiliation":[{"name":"Department of Paediatrics AZ Sint\u2010Jan Brugge  Bruges Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Van Aken","sequence":"additional","affiliation":[{"name":"Department of Paediatrics University Hospital Ghent  Ghent Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ellen","family":"Maris","sequence":"additional","affiliation":[{"name":"Department of Paediatrics VITAZ  Sint\u2010Niklaas Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4055-5233","authenticated-orcid":false,"given":"Chantal","family":"Mathieu","sequence":"additional","affiliation":[{"name":"Department of Endocrinology University Hospitals Leuven\u2014Department of Clinical and Experimental Endocrinology, KU Leuven  Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9111-4561","authenticated-orcid":false,"given":"Pieter","family":"Gillard","sequence":"additional","affiliation":[{"name":"Department of Endocrinology University Hospitals Leuven\u2014Department of Clinical and Experimental Endocrinology, KU Leuven  Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9690-3551","authenticated-orcid":false,"given":"Kristina","family":"Casteels","sequence":"additional","affiliation":[{"name":"Department of Paediatrics University Hospitals Leuven\u2014Department of Development and Regeneration, KU Leuven  Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,10,27]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/pedi.13427"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/DMRR.3842"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1159\/000543034"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/S00125\u2010024\u201006165\u2010W"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213\u20108587(25)00091\u20109"},{"key":"e_1_2_10_7_1","unstructured":"U.S. Food and Drug Administration.Use of Real\u2010World Evidence to Support Regulatory Decision\u2010Making for Medical Devices.2018. 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