{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T19:38:47Z","timestamp":1772998727508,"version":"3.50.1"},"reference-count":31,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,11,10]],"date-time":"2025-11-10T00:00:00Z","timestamp":1762732800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,11,10]],"date-time":"2025-11-10T00:00:00Z","timestamp":1762732800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100004312","name":"Eli Lilly and Company","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004312","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["dom-pubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabetes Obesity Metabolism"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>To investigate associations between glycaemic control and normal body mass index (BMI) and the long\u2010term risk of 3\u2010point major adverse cardiovascular events (3P\u2010MACE) in patients with type 2 diabetes (T2D).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>Adults with T2D and \u22651 glycated haemoglobin (HbA1c) and BMI record between 1 January 2007 and 31 October 2016 were included from the regional health information system of Yinzhou district, Ningbo, China. The index population comprised patients with HbA1c records \u22653\u2009months after the initial T2D diagnosis and BMI records after the initial T2D diagnosis. Of these, patients with \u22651 BMI record after the index date were included in the sustained population. Analyses were conducted using Cox proportional hazards models.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The index population included 5757 patients (median follow\u2010up 6.8\u2009years; 1188 [20.6%] experienced 3P\u2010MACE). In this population, the 3P\u2010MACE risk was significantly reduced in patients with glycaemic control and normal BMI (18.5\u201323.9\u2009kg\/m\n                      <jats:sup>2<\/jats:sup>\n                      ) versus neither glycaemic control nor normal BMI using HbA1c cutoffs of &lt;7.0% (adjusted hazard ratio [aHR] 0.73; 95% CI 0.62\u20130.86;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001) and \u22646.5% (aHR 0.76; 95% CI 0.64\u20130.90;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.001). In the sustained population (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20095513), the risk of 3P\u2010MACE was significantly reduced in patients with sustained glycaemic control and normal BMI versus neither sustained glycaemic control nor normal BMI using HbA1c cutoffs of &lt;7.0% (aHR 0.67; 95% CI 0.49\u20130.91;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.012) and \u22646.5% (aHR 0.69; 95% CI 0.50\u20130.94;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.020).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Index and sustained glycaemic control and normal BMI were associated with significant risk reduction in 3P\u2010MACE among Chinese patients with T2D.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/dom.70237","type":"journal-article","created":{"date-parts":[[2025,11,10]],"date-time":"2025-11-10T08:31:33Z","timestamp":1762763493000},"page":"606-614","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The association between glycaemic control, normal weight and long\u2010term macrovascular outcomes in people with type 2 diabetes in China: A retrospective study"],"prefix":"10.1111","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4334-6805","authenticated-orcid":false,"given":"Feng","family":"Sun","sequence":"first","affiliation":[{"name":"Department of Epidemiology and Biostatistics, School of Public Health Peking University  Beijing China"},{"name":"Key Laboratory of Epidemiology of Major Diseases (Peking University), Ministry of Education  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meng","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics, School of Public Health Peking University  Beijing China"},{"name":"Key Laboratory of Epidemiology of Major Diseases (Peking University), Ministry of Education  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2567-1439","authenticated-orcid":false,"given":"Qi","family":"Pan","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine Chinese Academy of Medical Sciences  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peng","family":"Shen","sequence":"additional","affiliation":[{"name":"Yinzhou District Center for Disease Control and Prevention  Ningbo City Zhejiang Province China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yexiang","family":"Sun","sequence":"additional","affiliation":[{"name":"Yinzhou District Center for Disease Control and Prevention  Ningbo City Zhejiang Province China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongbo","family":"Lin","sequence":"additional","affiliation":[{"name":"Yinzhou District Center for Disease Control and Prevention  Ningbo City Zhejiang Province China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7252-5349","authenticated-orcid":false,"given":"Siyan","family":"Zhan","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics, School of Public Health Peking University  Beijing China"},{"name":"Key Laboratory of Epidemiology of Major Diseases (Peking University), Ministry of Education  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6863-1798","authenticated-orcid":false,"given":"Lixin","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine Chinese Academy of Medical Sciences  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,11,10]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0140\u20106736(24)02317\u20101"},{"key":"e_1_2_9_3_1","unstructured":"International Diabetes Federation.IDF Diabetes Atlas. 10th ed. 2021. 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