{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T06:36:21Z","timestamp":1780554981997,"version":"3.54.1"},"reference-count":26,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T00:00:00Z","timestamp":1761523200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T00:00:00Z","timestamp":1761523200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100005089","name":"Natural Science Foundation of Beijing Municipality","doi-asserted-by":"publisher","award":["7252025"],"award-info":[{"award-number":["7252025"]}],"id":[{"id":"10.13039\/501100005089","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005089","name":"Natural Science Foundation of Beijing Municipality","doi-asserted-by":"publisher","award":["7252029"],"award-info":[{"award-number":["7252029"]}],"id":[{"id":"10.13039\/501100005089","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005089","name":"Natural Science Foundation of Beijing Municipality","doi-asserted-by":"publisher","award":["7254332"],"award-info":[{"award-number":["7254332"]}],"id":[{"id":"10.13039\/501100005089","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82171217"],"award-info":[{"award-number":["82171217"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["dom-pubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabetes Obesity Metabolism"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>Effective, targeted drug therapies for diabetic polyneuropathy (DP) are currently lacking. This study was designed to pinpoint new drug targets to enhance treatment efficacy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>\n                      Using large\u2010scale clinical and genetic datasets, we scrutinised proteins potentially involved in the onset and progression of\n                      <jats:styled-content style=\"fixed-case\">DP<\/jats:styled-content>\n                      . We further probed their associations with clinical symptoms and risk factors, and explored potential pathogenic mechanisms via single\u2010cell sequencing.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      We identified six proteins linked to\n                      <jats:styled-content style=\"fixed-case\">DP<\/jats:styled-content>\n                      , with Tumour Necrosis Factor Receptor Superfamily Member 14 (\n                      <jats:styled-content style=\"fixed-case\">TNFRSF14<\/jats:styled-content>\n                      ) standing out as a particularly compelling target. Notably,\n                      <jats:styled-content style=\"fixed-case\">TNFRSF14<\/jats:styled-content>\n                      levels correlated with clinical scale (as assessed by the Michigan Neuropathy Screening Instrument) and might mediate the impact of metabolic syndrome on\n                      <jats:styled-content style=\"fixed-case\">DP<\/jats:styled-content>\n                      . At the cellular level, single\u2010cell sequencing hinted that\n                      <jats:styled-content style=\"fixed-case\">TNFRSF14<\/jats:styled-content>\n                      could drive\n                      <jats:styled-content style=\"fixed-case\">DP<\/jats:styled-content>\n                      progression by activating macrophages and compromising endothelial cell function.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>TNFRSF14 emerges as a promising biomarker and therapeutic target for the early detection and specific treatment of DP, paving the way for improved patient outcomes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/dom.70239","type":"journal-article","created":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T04:22:27Z","timestamp":1761625347000},"page":"615-624","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Plasma proteomics identifies potential drug targets for diabetic polyneuropathy: Evidence from prospective cohorts and genetic analysis"],"prefix":"10.1111","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-6920-8081","authenticated-orcid":false,"given":"Haoning","family":"Lan","sequence":"first","affiliation":[{"name":"Department of Anaesthesiology Beijing Friendship Hospital, Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Songchao","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology Beijing Friendship Hospital, Capital Medical University  Beijing 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