{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T19:39:20Z","timestamp":1772998760114,"version":"3.50.1"},"reference-count":45,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T00:00:00Z","timestamp":1761523200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T00:00:00Z","timestamp":1761523200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82301651"],"award-info":[{"award-number":["82301651"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82371294"],"award-info":[{"award-number":["82371294"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2022YFC2502400"],"award-info":[{"award-number":["2022YFC2502400"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2022YFC2502403"],"award-info":[{"award-number":["2022YFC2502403"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["dom-pubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabetes Obesity Metabolism"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>To evaluate the relationship between metabolic syndrome and the efficacy and safety of genotype\u2010guided dual antiplatelet therapy (DAPT) in the CHANCE\u20102 trial.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and methods<\/jats:title>\n                    <jats:p>This post hoc study used data from the CHANCE\u20102 trial. Patients with minor stroke or TIA who carried the CYP2C19 loss\u2010of\u2010function (LOF) allele were randomized to receive ticagrelor\u2010aspirin (TIC\u2010ASA) or clopidogrel\u2010aspirin (CLO\u2010ASA). The primary efficacy outcome was stroke recurrence within 90\u2009days. The primary safety outcome was severe or moderate bleeding within 90\u2009days. We classified patients into metabolic syndrome (MetS) and non\u2010metabolic syndrome (non\u2010MetS) groups. Differences in the outcome during 90\u2010days follow\u2010up period were assessed using the Cox proportional hazards model.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Among 5652 patients, 3305 were non\u2010MetS and 2347 were MetS. Compared with CLO\u2010ASA, TIC\u2010ASA significantly reduced the risk of stroke recurrence within 90\u2009days among patients with MetS (6.44% vs. 9.90%; HR 0.64, 95% CI 0.48\u20130.85;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.01); this benefit was not seen in non\u2010MetS (6.03% vs. 5.96%; HR 1.01, 95% CI 0.77\u20131.34;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.93), with a significant interaction effect (\n                      <jats:italic>p for interaction<\/jats:italic>\n                      \u2009=\u20090.03). Moreover, a linear trend was observed (\n                      <jats:italic>p for trend<\/jats:italic>\n                      \u2009=\u20090.04), indicating metabolic health status may modify the efficacy of genotype\u2010guided DAPT in a dose\u2010dependent manner. No significant difference was observed in severe or moderate bleeding events by metabolic syndrome (MetS: 0.42% vs. 0.35%, non\u2010MetS: 0.25% vs. 0.36%;\n                      <jats:italic>p for interaction<\/jats:italic>\n                      \u2009=\u20090.55).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Among CYP2C19 LOF carriers with minor stroke or TIA, patients with MetS received more clinical benefit from TIC\u2010ASA versus CLO\u2010ASA compared to those with non\u2010MetS.<\/jats:p>\n                    <jats:p>\n                      Registry:\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"https:\/\/clinicaltrials.gov\/\">ClinicalTrials.gov<\/jats:ext-link>\n                      , TRN: NCT04078737.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/dom.70243","type":"journal-article","created":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T13:26:58Z","timestamp":1761658018000},"page":"625-633","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Genotype\u2010guided dual antiplatelet therapy in minor stroke or transient ischemic attack with metabolic syndrome: A post hoc analysis of\n                    <scp>CHANCE<\/scp>\n                    \u20102"],"prefix":"10.1111","volume":"28","author":[{"given":"Zhiyuan","family":"Feng","sequence":"first","affiliation":[{"name":"Department of Neurology, Beijing Tiantan Hospital Capital Medical University  Beijing China"},{"name":"China National Clinical Research Center for Neurological Diseases  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6471-3956","authenticated-orcid":false,"given":"Fangyuan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Neurology, Beijing Tiantan Hospital Capital Medical University  Beijing China"},{"name":"China National Clinical Research Center for Neurological Diseases  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aoming","family":"Jin","sequence":"additional","affiliation":[{"name":"China National Clinical Research Center for Neurological Diseases  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xinchen","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Neurology, Beijing Tiantan Hospital Capital Medical University  Beijing China"},{"name":"China National Clinical Research Center for Neurological Diseases  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yimeng","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Neurology, Beijing Tiantan Hospital Capital Medical University  Beijing China"},{"name":"China National Clinical Research Center for Neurological Diseases  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qi","family":"Chu","sequence":"additional","affiliation":[{"name":"Department of Neurology, Beijing Tiantan Hospital Capital Medical University  Beijing China"},{"name":"China National Clinical Research Center for Neurological Diseases  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing","family":"Xue","sequence":"additional","affiliation":[{"name":"Department of Neurology, Beijing Tiantan Hospital Capital Medical University  Beijing China"},{"name":"China National Clinical Research Center for Neurological Diseases  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aichun","family":"Cheng","sequence":"additional","affiliation":[{"name":"Department of Neurology, Beijing Tiantan Hospital Capital Medical University  Beijing China"},{"name":"China National Clinical Research Center for Neurological Diseases  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jinxi","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Neurology, Beijing Tiantan Hospital Capital Medical University  Beijing China"},{"name":"China National Clinical Research Center for Neurological Diseases  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hao","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Neurology, Beijing Tiantan Hospital Capital Medical University  Beijing China"},{"name":"China National Clinical Research Center for Neurological Diseases  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xia","family":"Meng","sequence":"additional","affiliation":[{"name":"Department of Neurology, Beijing Tiantan Hospital Capital Medical University  Beijing China"},{"name":"China National Clinical Research Center for Neurological Diseases  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yongjun","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Neurology, Beijing Tiantan Hospital Capital Medical University  Beijing China"},{"name":"China National Clinical Research Center for Neurological Diseases  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-7337-5628","authenticated-orcid":false,"given":"Jie","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Neurology, Beijing Tiantan Hospital Capital Medical University  Beijing China"},{"name":"China National Clinical Research Center for Neurological Diseases  Beijing China"},{"name":"Institutes of Brain Science Wannan Medical College  Wuhu China"},{"name":"Department of Neurology The First Affiliated Hospital of Wannan Medical College (Yijishan Hospital of Wannan Medical College)  Wuhu China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,10,27]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41569\u2010018\u20100119\u20104"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/s2213\u20108587(13)70062\u20107"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/s2213\u20108587(23)00086\u20104"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2020.01.226"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2004.09.067"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1586\/ern.10.203"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.5551\/jat.26765"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/fjc.0000000000000288"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1136\/svn\u20102020\u2010000791"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1161\/circulationaha.105.169404"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0140\u20106736(05)67402\u20108"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1161\/circulationaha.109.192644"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cccn.2004.08.012"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.284.22.2901"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.Str.0000080935.01264.91"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/joim.13142"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1506930"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa061894"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1161\/strokeaha.109.550228"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2009.04.028"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2008.12.011"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1212\/wnl.0000000000012415"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1177\/1076029613481102"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010020\u201059663\u20103"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jstrokecerebrovasdis.2022.106448"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1161\/jaha.122.026482"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.11909\/j.issn.1671\u20105411.2015.04.009"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.carrev.2015.08.007"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1161\/jaha.117.005650"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehq325"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2006.10.025"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1751\u20107176.2010.00307.x"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1055\/s\u20100037\u20101613694"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvu137"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2009.03.019"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.1161\/circoutcomes.109.890707"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0904327"},{"key":"e_1_2_11_39_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev\u2010pharmtox\u2010010814\u2010124354"},{"key":"e_1_2_11_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vph.2020.106819"},{"key":"e_1_2_11_41_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40265\u2010013\u20100126\u2010z"},{"key":"e_1_2_11_42_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00406\u2010025\u201001974\u20105"},{"key":"e_1_2_11_43_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0260229"},{"key":"e_1_2_11_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.numecd.2015.12.015"},{"key":"e_1_2_11_45_1","doi-asserted-by":"publisher","DOI":"10.1503\/cmaj.231262"},{"key":"e_1_2_11_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.numecd.2019.09.018"}],"container-title":["Diabetes, Obesity and Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dom-pubs.pericles-prod.literatumonline.com\/doi\/pdf\/10.1111\/dom.70243","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/dom-pubs.pericles-prod.literatumonline.com\/doi\/full-xml\/10.1111\/dom.70243","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/dom-pubs.pericles-prod.literatumonline.com\/doi\/pdf\/10.1111\/dom.70243","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T16:57:20Z","timestamp":1772989040000},"score":1,"resource":{"primary":{"URL":"https:\/\/dom-pubs.pericles-prod.literatumonline.com\/doi\/10.1111\/dom.70243"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10,27]]},"references-count":45,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["10.1111\/dom.70243"],"URL":"https:\/\/doi.org\/10.1111\/dom.70243","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.1111\/DOM.70243\/v1\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/DOM.70243\/v1\/review1","asserted-by":"object"}]},"ISSN":["1462-8902","1463-1326"],"issn-type":[{"value":"1462-8902","type":"print"},{"value":"1463-1326","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,10,27]]},"assertion":[{"value":"2025-09-26","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-10-19","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-10-27","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}