{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T11:07:24Z","timestamp":1791976044052,"version":"4.4.0"},"reference-count":29,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,11,10]],"date-time":"2025-11-10T00:00:00Z","timestamp":1762732800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,11,10]],"date-time":"2025-11-10T00:00:00Z","timestamp":1762732800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["dom-pubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabetes Obesity Metabolism"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>To compare the glycaemic efficacy, continuous glucose monitoring (CGM) metrics, and safety of biweekly efsubaglutide alfa 3\u2009mg (Q2W) versus weekly 1\u2009mg (QW) in adults with type 2 diabetes inadequately controlled with lifestyle intervention.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>\n                      In this multicentre, randomised, open\u2010label trial, 59 adults were allocated 1:1 to efsubaglutide alfa 3\u2009mg Q2W or 1\u2009mg QW for 12\u2009weeks after a 1\u2010week 1\u2009mg run\u2010in. The primary endpoint was change in HbA1c from baseline to week\u200913 (end of 12\u2010week treatment). Secondary endpoints included fasting plasma glucose (FPG), CGM time in range (TIR, 3.9\u201310.0\u2009mmol\/L) and tight TIR (3.9\u20137.8\u2009mmol\/L), 24\u2010h mean glucose, weight, lipids, and adverse events. Continuous outcomes were analysed using a mixed model for repeated measures (MMRM); categorical outcomes used stratified Mantel\u2013Haenszel tests;\n                      <jats:italic>p<\/jats:italic>\n                      values\/CI were descriptive.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>HbA1c decreased by \u22121.45% (SE\u20090.14) with Q2W and \u22121.53% (0.14) with QW; LS mean difference (Q2W\u2013QW) 0.09% (95%\u2009CI \u22120.32, 0.50). FPG fell similarly (\u22122.07 vs. \u22122.22\u2009mmol\/L). TIR increased from 45.0% to 77.2% with Q2W and 75.1% with QW; tight TIR reached 53.8% and 48.8%, respectively. End\u2010of\u2010treatment 24\u2010h mean CGM glucose was 8.12 versus 8.66\u2009mmol\/L (Q2W vs. QW). At week\u200913, HbA1c &lt;7.0% was achieved by 55.2% (Q2W) and 65.5% (QW); \u22646.5% by 37.9% and 24.1%. Gastrointestinal adverse events predominated and were mostly mild to moderate; no hypoglycaemia or cardiovascular events occurred.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Over 12\u2009weeks, efsubaglutide alfa 3\u2009mg Q2W provided glycaemic and CGM benefits comparable to 1\u2009mg QW with favourable tolerability. These findings support the feasibility of a biweekly regimen as an alternative to weekly dosing; larger, longer\u2010duration confirmatory trials in more diverse populations are warranted.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/dom.70262","type":"journal-article","created":{"date-parts":[[2025,11,10]],"date-time":"2025-11-10T09:32:06Z","timestamp":1762767126000},"page":"925-934","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Biweekly dosing of efsubaglutide alfa maintains glycaemic and continuous glucose monitoring control in type 2 diabetes: A randomised multicentre trial"],"prefix":"10.1111","volume":"28","author":[{"given":"Rui","family":"Sun","sequence":"first","affiliation":[{"name":"Department of Endocrinology Nanjing First Hospital, Nanjing Medical University  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Endocrinology Nanjing First Hospital, Nanjing Medical University  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongyan","family":"Shu","sequence":"additional","affiliation":[{"name":"Department of Endocrinology Zibo Municipal Hospital  Zibo China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Endocrinology The First Affiliated Hospital of Ningbo University  Ningbo China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianping","family":"Yao","sequence":"additional","affiliation":[{"name":"Department of Endocrinology Huzhou Central Hospital Affiliated to Central Hospital of Huzhou University  Huzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiuhai","family":"Su","sequence":"additional","affiliation":[{"name":"Department of Endocrinology Cangzhou Hospital of Integrated TCM and Western Medicine in Hebei Province  Cangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bimin","family":"Shi","sequence":"additional","affiliation":[{"name":"Department of Endocrinology The First Affiliated Hospital of Soochow University  Suzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chaoming","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Endocrinology The Second Affiliated Hospital of Wenzhou Medical University  Wenzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianhua","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Endocrinology Nanjing First Hospital, Nanjing Medical University  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6478-0988","authenticated-orcid":false,"given":"Qinghua","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism Huashan Hospital, Shanghai Medical School, Fudan University  Shanghai China"},{"name":"Innogen Pharmaceutical Co. 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