{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T16:40:39Z","timestamp":1776444039475,"version":"3.51.2"},"reference-count":41,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,11,17]],"date-time":"2025-11-17T00:00:00Z","timestamp":1763337600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,11,17]],"date-time":"2025-11-17T00:00:00Z","timestamp":1763337600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100003819","name":"Natural Science Foundation of Hubei Province","doi-asserted-by":"publisher","award":["2023AFC041"],"award-info":[{"award-number":["2023AFC041"]}],"id":[{"id":"10.13039\/501100003819","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["dom-pubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabetes Obesity Metabolism"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>Hypoglycemia is one of the most common and challenging adverse events in diabetes management. Recurrent episodes increase both the economic burden and all\u2010cause mortality among elderly patients with diabetes living at home. This study aimed to develop and internally validate a nomogram based on real\u2010world data to predict 6\u2010month hypoglycemia risk in elderly community\u2010dwelling type 2 diabetes mellitus (T2DM) patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and methods<\/jats:title>\n                    <jats:p>A multicentre prospective cohort of 815 elderly T2DM patients was recruited from five community health centres between 1 March 2024 and 31 May 2024. Each participant was followed for 6\u2009months after enrolment. The primary endpoint was the first hypoglycemic event during follow\u2010up. Candidate variables identified by univariate analysis were refined via least absolute shrinkage and selection operator (LASSO) regression and incorporated into multivariable logistic regression to construct the model. Internal validation was performed with bootstrap resampling. Model performance was assessed by the area under the receiver operating characteristic curve (AUC), calibration plots, decision curve analysis (DCA), and clinical impact curves (CIC).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The 6\u2010month cumulative incidence of hypoglycemia was 17.5% in the study. The final model included 10 independent predictors: history of hypoglycemia, HbA1c, BMI, self\u2010management ability, living situation, exercise intensity, frequency of blood glucose monitoring, medication use, insulin use, and hypoglycemia fear\u2013behaviour scale score. The model achieved an AUC of 0.80 with good calibration and clinical utility.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This nomogram accurately quantifies the 6\u2010month risk of hypoglycemia in elderly community\u2010dwelling T2DM patients. It provides evidence\u2010based decision support for hypoglycemia prevention in primary healthcare settings and may assist community physicians in delivering individualised chronic disease management.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/dom.70297","type":"journal-article","created":{"date-parts":[[2025,11,17]],"date-time":"2025-11-17T08:17:13Z","timestamp":1763367433000},"page":"1126-1135","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Nomogram\u2010based prediction of hypoglycemia risk in elderly community\u2010dwelling patients with type 2 diabetes: Development and validation in a multicentre real\u2010world cohort"],"prefix":"10.1111","volume":"28","author":[{"given":"Lingxue","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Endocrinology The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology  Wuhan 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