{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T23:18:07Z","timestamp":1780615087184,"version":"3.54.1"},"reference-count":27,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,11,20]],"date-time":"2025-11-20T00:00:00Z","timestamp":1763596800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2025,11,20]],"date-time":"2025-11-20T00:00:00Z","timestamp":1763596800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["dom-pubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabetes Obesity Metabolism"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>This study aimed to investigate the efficacy and safety of bi\u2010weekly cofrogliptin treatment as a replacement for daily dipeptidyl peptidase\u20104 inhibitors (DPP\u20104is) in Chinese patients with type 2 diabetes mellitus (T2DM).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This multicenter, open\u2010label, randomized controlled study assigned participants in a 1:1 ratio to either the daily DPP\u20104i group or the 10\u2009mg cofrogliptin group. The DPP\u20104i group continued their original daily DPP\u20104i regimen for 24\u2009weeks, whereas the cofrogliptin group discontinued the daily DPP\u20104i and received the investigational drug orally once every 2\u2009weeks. All participants underwent 14\u2010day continuous glucose monitoring at weeks 10\u201312 and 22\u201324 during the treatment period. The main endpoint was the change in glucose time in range (TIR; 3.9\u201310.0\u2009mmol\/L) from baseline to week 24. Additionally, the Diabetes Treatment Satisfaction Questionnaire scores, adverse events, and hypoglycaemic events were compared between groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The enrolment period was from 31 January 2024 to 20 November 2024. A total of 64 participants were randomized to receive either cofrogliptin (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200931) or a daily DPP\u20104i (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200933). The least squares (LS) mean (standard error) change in TIR from baseline after 24\u2009weeks was 0.037%\u2009\u00b1\u20092.506% in the cofrogliptin group compared to \u22129.891%\u2009\u00b1\u20092.435% in the daily DPP\u20104i group. The LS mean difference was 9.929% (95% confidence interval: 3.064%\u201316.793%), which was statistically significant (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.0046). The incidence, classification, and severity of adverse events were similar between the two groups.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Bi\u2010weekly cofrogliptin treatment, instead of daily DPP\u20104i, could effectively control blood glucose levels in a 24\u2010week treatment period and their fluctuations and was well tolerated in Chinese patients with T2DM.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/dom.70305","type":"journal-article","created":{"date-parts":[[2025,11,21]],"date-time":"2025-11-21T04:56:09Z","timestamp":1763700969000},"page":"1191-1200","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Efficacy and safety of bi\u2010weekly cofrogliptin treatment replacing daily dipeptidyl peptidase\u20104 inhibitors in Chinese patients with type 2 diabetes mellitus: A multicenter, open\u2010label, randomized controlled phase 2 trial"],"prefix":"10.1111","volume":"28","author":[{"given":"Congqing","family":"Pan","sequence":"first","affiliation":[{"name":"NHC Key Laboratory of Hormones and Development, Tianjin Key Laboratory of Metabolic Diseases, Chu Hsien\u2010I Memorial Hospital &amp; Tianjin Institute of Endocrinology Tianjin Medical University  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongwei","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of endocrinology The First Affiliated Hospital of Henan University of Science &amp; Technology  Luoyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Feng","sequence":"additional","affiliation":[{"name":"Department of endocrinology Zhongshan City People's Hospital  Zhongshan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suijun","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Shidong Hospital Shidong Hospital Affiliated to University of Shanghai for Science and Technology  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Endocrinology The People's Hospital of Leshan  Leshan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhongjing","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Endocrinology The Central Hospital of Wuhan  Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yusen","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Endocrinology The People's Hospital of Bozhou  Bozhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fangqiong","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine Haisco Pharmaceutical Group Co, Ltd  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhanhui","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine Haisco Pharmaceutical Group Co, Ltd  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaming","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine Haisco Pharmaceutical Group Co, Ltd  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5682-2340","authenticated-orcid":false,"given":"Liming","family":"Chen","sequence":"additional","affiliation":[{"name":"NHC Key Laboratory of Hormones and Development, Tianjin Key Laboratory of Metabolic Diseases, Chu Hsien\u2010I Memorial Hospital &amp; 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