{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T16:08:55Z","timestamp":1791994135827,"version":"4.4.0"},"reference-count":118,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,11,24]],"date-time":"2025-11-24T00:00:00Z","timestamp":1763942400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,11,24]],"date-time":"2025-11-24T00:00:00Z","timestamp":1763942400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["dom-pubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabetes Obesity Metabolism"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>Polycystic ovary syndrome (PCOS) is a common endocrine disorder in reproductive\u2010age women, associated with insulin resistance, hyperandrogenism, and menstrual irregularities. Nutraceutical interventions\u2014bioactive compounds derived from foods or supplements that provide health benefits beyond basic nutrition\u2014may support conventional therapy. This study aimed to systematically evaluate the effects of nutraceutical interventions on reproductive and metabolic outcomes in PCOS.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>This systematic review and meta\u2010analysis was registered in PROSPERO (CRD42024521879) and followed PRISMA 2020. Searches were performed in PubMed, Embase, Cochrane Library, Web of Science, and regional databases (January 2013\u2013December 2024) and included 78 eligible studies. Eligible randomized and quasi\u2010experimental studies assessed nutraceuticals such as vitamin D, inositol, and quercetin. Risk of bias was evaluated with standardized tools; certainty of evidence was graded by GRADE.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Seventy\u2010eight studies met inclusion criteria. Nutraceutical interventions significantly reduced fasting insulin (MD\u2009=\u2009\u22122.14 \u03bcIU\/mL; 95% CI \u20133.12 to \u22121.16) and luteinizing hormone (MD\u2009=\u2009\u22121.34 mIU\/mL; 95% CI \u20132.10 to \u22120.58) and increased sex\u2010hormone\u2010binding globulin (MD\u2009=\u2009+3.72\u2009nmol\/L; 95% CI 1.35 to 6.09). Vitamin D supplementation showed the strongest metabolic and hormonal improvements. Results for ovarian follicle count and menstrual bleeding were inconsistent.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Nutraceutical interventions targeting metabolic and hormonal regulation may complement lifestyle therapy in women with PCOS. Interpretation is limited by study heterogeneity and variable methodological quality. No external funding was received.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/dom.70307","type":"journal-article","created":{"date-parts":[[2025,11,25]],"date-time":"2025-11-25T05:32:19Z","timestamp":1764048739000},"page":"1213-1233","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["The effect of nutraceutical interventions on reproductive health outcomes in women with polycystic ovary syndrome: A systematic review and meta\u2010analysis"],"prefix":"10.1111","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4622-9252","authenticated-orcid":false,"given":"Zehra Margot","family":"\u00c7elik","sequence":"first","affiliation":[{"name":"Department of Nutrition and Dietetics, Faculty of Health Science Marmara University  Istanbul 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