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A Multisensory Dysfunction Index (\n                      <jats:styled-content style=\"fixed-case\">MSDI<\/jats:styled-content>\n                      ) was constructed to quantify integrated sensory dysfunction, and moderated mediation analysis was performed to examine the impact of sensory complications on cognitive function.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The\n                      <jats:styled-content style=\"fixed-case\">MSDI<\/jats:styled-content>\n                      was correlated with sensory complication burden and associated with worse global cognitive performance (Montreal Cognitive Assessment,\n                      <jats:styled-content style=\"fixed-case\">MoCA<\/jats:styled-content>\n                      ). Mediation analysis showed that odour identification mediated the relationship between\n                      <jats:styled-content style=\"fixed-case\">MSDI<\/jats:styled-content>\n                      and\n                      <jats:styled-content style=\"fixed-case\">MoCA<\/jats:styled-content>\n                      in\n                      <jats:styled-content style=\"fixed-case\">T2D<\/jats:styled-content>\n                      . This indirect effect was absent in diabetic peripheral neuropathy (\n                      <jats:styled-content style=\"fixed-case\">DPN<\/jats:styled-content>\n                      )+ individuals but remained significant in\n                      <jats:styled-content style=\"fixed-case\">DPN<\/jats:styled-content>\n                      \u2212 individuals. Additionally, olfactory dysfunction had both direct and indirect effects on cognition in\n                      <jats:styled-content style=\"fixed-case\">DPN<\/jats:styled-content>\n                      \u2212 patients.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      Our findings highlight the central role of olfactory dysfunction in linking multisensory impairment to cognitive decline in\n                      <jats:styled-content style=\"fixed-case\">T2D<\/jats:styled-content>\n                      . The results emphasize the need for personalized management strategies based on sensory complications and suggest that preserving sensory network integrity may help maintain olfactory and cognitive health in\n                      <jats:styled-content style=\"fixed-case\">T2D<\/jats:styled-content>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/dom.70309","type":"journal-article","created":{"date-parts":[[2025,11,25]],"date-time":"2025-11-25T08:10:03Z","timestamp":1764058203000},"page":"1234-1246","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Sensory network dysregulation in type 2 diabetes: Linking olfactory, visual, and cognitive function"],"prefix":"10.1111","volume":"28","author":[{"given":"Qian","family":"Li","sequence":"first","affiliation":[{"name":"Department of Radiology, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School Nanjing 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