{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T10:15:00Z","timestamp":1775816100347,"version":"3.50.1"},"reference-count":15,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,11,25]],"date-time":"2025-11-25T00:00:00Z","timestamp":1764028800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,11,25]],"date-time":"2025-11-25T00:00:00Z","timestamp":1764028800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001782","name":"University of Melbourne","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001782","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["dom-pubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabetes Obesity Metabolism"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>We aimed to evaluate sensor accuracy and insulin delivery integrity of a novel device combining continuous glucose monitoring (CGM) with an insulin delivering cannula (CGM\u2010IS) (Pacific Diabetes Technologies, Portland, Oregon, USA) during 7\u2010day wear, in adults with type 1 diabetes (T1D).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>This single centre, single arm, non\u2010randomised study involves 40 T1D adults who were using insulin pumps and CGM for 7\u2009days, with three meal test days and four free living days. The main endpoints were sensor accuracy according to mean average relative difference (MARD) and infusion set function reflected by time in range (TIR), mean sensor glucose and total daily dose (TDD) of insulin.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Sensor MARD was 16.4%, 14.8% and 17.7% on Days 1, 4 and 7, respectively. 60.0% of readings met the 15\/15 criterion for blood glucose (BG) readings &lt;70.2\u2009mg\/dL. Insulin delivery integrity was maintained to Day 3. At Days 5\u20136 TDD increased by 7.3\u2009units\/day (16%), mean BG increased by 16.2\u2009mg\/dL (10.2%), and TIR fell by \u22127.8% (11.2%). 92.1% of devices lasted &gt;4\u2009days. Mean wear time was 6.3\u2009\u00b1\u20091.4\u2009days. The device was well tolerated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This human feasibility study supports the potential of CGM\u2010IS use for up to 7\u2009days with a mean survival of over 6\u2009days. However, our data indicate that the durability of insulin delivery and sensor refinement are required prior to commercialisation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/dom.70331","type":"journal-article","created":{"date-parts":[[2025,11,26]],"date-time":"2025-11-26T03:51:57Z","timestamp":1764129117000},"page":"1403-1410","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Feasibility study of a combined insulin\u2010delivery and glucose sensor system worn over 7\u2009days in persons with type 1 diabetes"],"prefix":"10.1111","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-1263-3344","authenticated-orcid":false,"given":"Hannah","family":"Cunningham","sequence":"first","affiliation":[{"name":"Department of Medicine St Vincent's Hospital Melbourne, The University of Melbourne  Fitzroy Victoria 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