{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T17:43:58Z","timestamp":1792172638110,"version":"4.4.0"},"reference-count":38,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,12,5]],"date-time":"2025-12-05T00:00:00Z","timestamp":1764892800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2025,12,5]],"date-time":"2025-12-05T00:00:00Z","timestamp":1764892800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100015835","name":"Department of Health, Taipei City Government","doi-asserted-by":"publisher","award":["11401\u201062\u2010007"],"award-info":[{"award-number":["11401\u201062\u2010007"]}],"id":[{"id":"10.13039\/501100015835","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["dom-pubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabetes Obesity Metabolism"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>To assess whether periconceptional exposure to glucagon\u2010like peptide\u20101 receptor agonists (GLP\u20101 RAs) is associated with adverse outcomes in women with pregestational type 2 diabetes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>We linked Taiwan's Birth Certificate Application and National Health Insurance claims (2013\u20132022) to assemble a nationwide cohort of singleton births to mothers (18\u201350\u2009years) with pregestational diabetes. Exposure was any GLP\u20101 RA dispensed during the 90\u2009days before and after the last menstrual period; insulin without GLP\u20101 RA was the active comparator. Outcomes were major congenital malformations, stillbirth, preterm birth (&lt;37\u2009weeks) and small for gestational age (SGA, &lt;10th percentile). We used 1:4 propensity\u2010score matching and Poisson generalised estimating equation (GEE); sensitivity analyses required \u22652 prescriptions and restricted exposure to the first trimester.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>We identified 3351 comparison pregnancies (GLP\u20101 RA 160; insulin 3191); matching yielded 160 versus 606. Risk ratios (GLP\u20101 RA vs. insulin) were malformations 0.64 (95% confidence interval 0.11\u20133.83), stillbirth 2.05 (0.82\u20135.13), preterm birth 1.09 (0.85\u20131.39) and SGA 0.86 (0.31\u20132.41). Sensitivity analyses were similar.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Periconceptional GLP\u20101 RA exposure was not associated with increased risks of malformations, stillbirth, preterm birth or SGA versus insulin use. These preliminary data require confirmation in larger agent\u2010specific studies; until then, intentional GLP\u20101 RA use in planned pregnancy is not advised.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/dom.70334","type":"journal-article","created":{"date-parts":[[2025,12,5]],"date-time":"2025-12-05T08:07:02Z","timestamp":1764922022000},"page":"1420-1430","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Unintentional periconceptional exposure to glucagon\u2010like peptide\u20101 receptor agonists and adverse pregnancy outcomes: A nationwide cohort study in Taiwan"],"prefix":"10.1111","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7478-0105","authenticated-orcid":false,"given":"Yi\u2010Chang","family":"Chou","sequence":"first","affiliation":[{"name":"Department of Health Promotion and Health Education National Taiwan Normal University  Taipei Taiwan"},{"name":"Department of 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