{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T17:18:30Z","timestamp":1788542310381,"version":"build-2803163510"},"reference-count":27,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,11,27]],"date-time":"2025-11-27T00:00:00Z","timestamp":1764201600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,11,27]],"date-time":"2025-11-27T00:00:00Z","timestamp":1764201600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["dom-pubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabetes Obesity Metabolism"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This study provides real\u2010world evidence on the comparative effectiveness of glucagon\u2010like peptide\u20101 receptor agonists (GLP\u20101 RAs) and sodium\u2010glucose cotransporter\u20102 inhibitors (SGLT2i) regarding the risk of incident dementia in adults with type 2 diabetes mellitus (T2DM).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Research Design and Methods<\/jats:title>\n                    <jats:p>This cohort study utilised electronic health records from TriNetX (1 April 2013 to 31 December 2019). Adults with T2DM on metformin who initiated GLP\u20101 RAs or SGLT2i were analysed using Cox proportional hazards models in 1:1 propensity score\u2010matched cohorts. The primary outcome was all\u2010cause dementia; secondary outcomes included vascular and Alzheimer's dementia. Confounding variables were adjusted.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Among 16\u2009271 participants using GLP\u20101 RAs and 16\u2009271 using SGLT2i over a median 6.3\u2010year follow\u2010up, 581 GLP\u20101 RA users and 572 SGLT2i users developed dementia. No significant differences were observed in all\u2010cause dementia (hazard ratio: 1.01, 95% confidence interval: 0.90\u20131.13), vascular, or Alzheimer's dementia. Subgroup analyses confirmed these findings.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>SGLT2i use was not associated with increased risk of dementia compared with GLP\u20101RAs in patients with T2DM. Further research is warranted to explore the effects of (newer) incretin\u2010based (co\u2010)agonists on cognitive outcomes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/dom.70336","type":"journal-article","created":{"date-parts":[[2025,11,28]],"date-time":"2025-11-28T02:44:20Z","timestamp":1764297860000},"page":"1443-1452","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Comparative effectiveness of sodium\u2010glucose cotransporter\u20102 inhibitors and glucagon\u2010like peptide\u20101 receptor agonists for incident dementia: A retrospective multicohort study"],"prefix":"10.1111","volume":"28","author":[{"given":"Filippos","family":"Anagnostakis","sequence":"first","affiliation":[{"name":"Centre for Biomedical Image Computing and Analytics University of Pennsylvania  Philadelphia Pennsylvania USA"},{"name":"Department of Medical and Surgical Sciences Alma Mater University of Bologna  Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0027-5659","authenticated-orcid":false,"given":"Michail","family":"Kokkorakis","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacy and Pharmacology University of Groningen, University Medical Center Groningen  Groningen The Netherlands"},{"name":"Department of Medicine Beth Israel Deaconess Medical Center, Harvard Medical School  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shrihari","family":"Nagarajan","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences, School of Medicine University of Missouri\u2010Kansas City  Kansas Missouri USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georgia","family":"Anastasiou","sequence":"additional","affiliation":[{"name":"Department of Medicine Beth Israel Deaconess Medical Center, Harvard Medical School  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3755-8158","authenticated-orcid":false,"given":"Christos S.","family":"Mantzoros","sequence":"additional","affiliation":[{"name":"Department of Medicine Beth Israel Deaconess Medical Center, Harvard Medical School  Boston Massachusetts USA"},{"name":"Section of Endocrinology Boston VA Healthcare System, Harvard Medical School  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,11,27]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(23)01301-6"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)30367-6"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc19-0783"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-021-05393-8"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-19-0259"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(20)30173-3"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eclinm.2024.102689"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj-2023-077097"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc24-S013"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40471-015-0053-5"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrrheum.2015.30"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1210\/endrev\/bnab007"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwv254"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2022.21383"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc22-1705"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000209805"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj-2024-079475"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1177\/13872877251319054"},{"issue":"1","key":"e_1_2_10_20_1","article-title":"Treatment 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