{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T22:14:15Z","timestamp":1773180855361,"version":"3.50.1"},"reference-count":50,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,12,15]],"date-time":"2025-12-15T00:00:00Z","timestamp":1765756800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,12,15]],"date-time":"2025-12-15T00:00:00Z","timestamp":1765756800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100006108","name":"National Center for Advancing Translational Sciences","doi-asserted-by":"publisher","award":["UL1TR001102"],"award-info":[{"award-number":["UL1TR001102"]}],"id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000738","name":"U.S. Department of Veterans Affairs","doi-asserted-by":"publisher","award":["5I01BX004102"],"award-info":[{"award-number":["5I01BX004102"]}],"id":[{"id":"10.13039\/100000738","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100016758","name":"Nutrition Obesity Research Center at Harvard","doi-asserted-by":"publisher","award":["P30DK040561"],"award-info":[{"award-number":["P30DK040561"]}],"id":[{"id":"10.13039\/100016758","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["5T32DK007028"],"award-info":[{"award-number":["5T32DK007028"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["K24MH120568"],"award-info":[{"award-number":["K24MH120568"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01DK109932"],"award-info":[{"award-number":["R01DK109932"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["dom-pubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabetes Obesity Metabolism"],"published-print":{"date-parts":[[2026,2]]},"abstract":"Abstract<\/jats:title>\n \n Background<\/jats:title>\n Exogenous oxytocin (OT) reduces reward\u2010driven food intake. Less is known about endogenous OT and eating behaviour. Preclinical studies suggest peripheral OT levels may reflect the opposite of central appetite\u2010related OT activity. In healthy females, circulating OT declines after eating. Whether this pattern exists in obesity and how endogenous OT relates to hedonic eating remains unclear. We hypothesised that OT would decrease postprandially in adults with obesity and that higher OT exposure, reflecting lower central OT signalling, would correlate with greater reward\u2010driven caloric intake.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n Sixty\u2010one adults with obesity (56% female; age [mean\u2009\u00b1\u2009SE] 33.55\u2009\u00b1\u20090.81\u2009years; BMI 36.77\u2009\u00b1\u20090.62\u2009kg\/m\n 2<\/jats:sup>\n ) consumed a standardised meal following an overnight fast. OT was measured in peripheral blood pre\u2010meal and 30, 60, and 120 min post\u2010meal. Area under the curve (AUC) was calculated to capture OT exposure. Postprandial hedonic eating drive was assessed via visual analogue scales (VAS) and Cookie Taste Test (CTT). Meal\u2010related OT dynamics were analysed using linear mixed effects models, relationships between OT exposure and hedonic eating drive were examined with linear regression and mediation analyses.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n OT levels did not change in response to the meal. Greater OT AUC was associated with reduced postprandial satisfaction (\n p<\/jats:italic>\n \u2009=\u20090.008,\n d<\/jats:italic>\n \u2009=\u20091.00) and higher CTT caloric intake (\n p<\/jats:italic>\n \u2009=\u20090.036,\n d<\/jats:italic>\n \u2009=\u20090.62). The relationship between OT AUC and CTT caloric intake was mediated by OT's effect on postprandial satisfaction (\n p<\/jats:italic>\n \u2009=\u20090.014, proportion mediated\u2009=\u200953.28%).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n In obesity, OT levels did not change postprandially. Greater OT exposure was linked to lower satisfaction and increased hedonic eating, suggesting dysregulated OT signalling in obesity potentially contributing to overeating.<\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/dom.70340","type":"journal-article","created":{"date-parts":[[2025,12,15]],"date-time":"2025-12-15T09:51:19Z","timestamp":1765792279000},"page":"1472-1481","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Oxytocin levels do not change around a meal and correlate with reward\u2010driven caloric consumption in adults with obesity"],"prefix":"10.1111","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3907-6630","authenticated-orcid":false,"given":"Marie\u2010Louis","family":"Wronski","sequence":"first","affiliation":[{"name":"Neuroendocrine Unit, Department of Medicine Massachusetts General Hospital and Harvard Medical School Boston Massachusetts USA"},{"name":"Translational Developmental Neuroscience Section, Division of Psychological and Social Medicine and Developmental Neurosciences, Faculty of Medicine Technische Universit\u00e4t Dresden Dresden Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Regine","family":"Boutin","sequence":"additional","affiliation":[{"name":"Neuroendocrine Unit, Department of Medicine Massachusetts General Hospital and Harvard Medical School Boston Massachusetts USA"},{"name":"Section of Endocrinology, Department of Medicine Temple University, Lewis Katz School of Medicine Philadelphia Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6439-8191","authenticated-orcid":false,"given":"Clara O.","family":"Sailer","sequence":"additional","affiliation":[{"name":"Neuroendocrine Unit, Department of Medicine Massachusetts General Hospital and Harvard Medical School Boston Massachusetts USA"},{"name":"Division of Endocrinology, Diabetes and Hypertension, Department of Medicine Brigham and Women's Hospital, Harvard Medical School Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesca","family":"Galbiati","sequence":"additional","affiliation":[{"name":"Neuroendocrine Unit, Department of Medicine Massachusetts General Hospital and Harvard Medical School Boston Massachusetts USA"},{"name":"Division of Endocrinology, Diabetes and Hypertension, Department of Medicine Brigham and Women's Hospital, Harvard Medical School Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Aulinas","sequence":"additional","affiliation":[{"name":"Department of Endocrinology Hospital de la Santa Creu i Sant Pau, IR\u2010Sant Pau, CIBERER Unidad 747, ISCIII Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maged","family":"Muhammed","sequence":"additional","affiliation":[{"name":"Neuroendocrine Unit, Department of Medicine Massachusetts General Hospital and Harvard Medical School Boston Massachusetts USA"},{"name":"Division of Endocrinology, Diabetes and Hypertension, Department of Medicine Brigham and Women's Hospital, Harvard Medical School Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kamryn T.","family":"Eddy","sequence":"additional","affiliation":[{"name":"Eating Disorders Clinical and Research Program, Department of Psychiatry Massachusetts General Hospital and Harvard Medical School Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jennifer J.","family":"Thomas","sequence":"additional","affiliation":[{"name":"Eating Disorders Clinical and Research Program, Department of Psychiatry Massachusetts General Hospital and Harvard Medical School Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liya","family":"Kerem","sequence":"additional","affiliation":[{"name":"Division of Pediatric Endocrinology, Department of Pediatrics Hadassah\u2010Hebrew University Medical Center Jerusalem Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C. Sue","family":"Carter","sequence":"additional","affiliation":[{"name":"Kinsey Institute Indiana University Bloomington Indiana USA"},{"name":"Department of Psychology University of Virginia Charlottesville Virginia USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shawn","family":"Nazarloo","sequence":"additional","affiliation":[{"name":"Kinsey Institute Indiana University Bloomington Indiana USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John M.","family":"Davis","sequence":"additional","affiliation":[{"name":"Department of Psychiatry University of Illinois at Chicago Chicago Illinois USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James E.","family":"Blevins","sequence":"additional","affiliation":[{"name":"Department of Veterans Affairs Medical Center VA Puget Sound Health Care System Office of Research and Development Medical Research Service Seattle Washington USA"},{"name":"Division of Metabolism Endocrinology and Nutrition Department of Medicine University of Washington School of Medicine Seattle Washington USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katherine","family":"Holman","sequence":"additional","affiliation":[{"name":"Neuroendocrine Unit, Department of Medicine Massachusetts General Hospital and Harvard Medical School Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julia","family":"Gydus","sequence":"additional","affiliation":[{"name":"Neuroendocrine Unit, Department of Medicine Massachusetts General Hospital and Harvard Medical School Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarah E.","family":"Smith","sequence":"additional","affiliation":[{"name":"Neuroendocrine Unit, Department of Medicine Massachusetts General Hospital and Harvard Medical School Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elisa","family":"Asanza","sequence":"additional","affiliation":[{"name":"Neuroendocrine Unit, Department of Medicine Massachusetts General Hospital and Harvard Medical School Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Franziska","family":"Plessow","sequence":"additional","affiliation":[{"name":"Neuroendocrine Unit, Department of Medicine Massachusetts General Hospital and Harvard Medical School Boston Massachusetts USA"},{"name":"Department of Psychiatry and Behavioral Sciences, Weill Institute for Neurosciences University of California San Francisco California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8619-3349","authenticated-orcid":false,"given":"Elizabeth A.","family":"Lawson","sequence":"additional","affiliation":[{"name":"Neuroendocrine Unit, Department of Medicine Massachusetts General Hospital and Harvard Medical School Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,12,15]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0031\u20109384(90)90234\u2010U"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.physbeh.2015.05.023"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00441.2014"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0025565"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22147737"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrendo.2017.115"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00296.2011"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/WNR.0000000000001005"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/jne.12381"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2013.03.026"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2010\u20100151"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00558.2005"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.physbeh.2019.112704"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.appet.2017.11.035"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/oby.21069"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1056\/EVIDoa2300349"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010018\u201020963\u20104"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/ijo.2016.149"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/npp.2017.226"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41366\u2010019\u20100489\u20107"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/oby.23010"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.2337\/db13\u20100663"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.23\u201032\u201010351.2003"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.3715453"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/jne.13303"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2019\u201000926"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1093\/ejendo\/lvaf154"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2018\u201002036"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2019.10.020"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cct.2022.106909"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psyneuen.2019.104556"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1037\/0021\u2010843X.103.3.505"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ijo.0801083"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.2337\/db11\u20101390"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.physbeh.2008.02.011"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psyneuen.2011.10.007"},{"key":"e_1_2_11_38_1","volume-title":"R: A Language and Environment for Statistical Computing","author":"R Core Team","year":"2024"},{"key":"e_1_2_11_39_1","doi-asserted-by":"publisher","DOI":"10.1093\/ejendo\/lvad087"},{"key":"e_1_2_11_40_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00196.2011"},{"key":"e_1_2_11_41_1","doi-asserted-by":"publisher","DOI":"10.1038\/ijo.2015.220"},{"key":"e_1_2_11_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmet.2025.102220"},{"key":"e_1_2_11_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006\u20108993(86)91519\u20102"},{"key":"e_1_2_11_44_1","doi-asserted-by":"publisher","DOI":"10.2174\/1745017901915010058"},{"key":"e_1_2_11_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psyneuen.2012.08.011"},{"key":"e_1_2_11_46_1","doi-asserted-by":"publisher","DOI":"10.1507\/endocrj1954.26.197"},{"key":"e_1_2_11_47_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2013\u20102605"},{"key":"e_1_2_11_48_1","doi-asserted-by":"publisher","DOI":"10.1210\/jcem\u201070\u20102\u2010473"},{"key":"e_1_2_11_49_1","doi-asserted-by":"publisher","DOI":"10.1210\/jcem\u201059\u20105\u2010949"},{"key":"e_1_2_11_50_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41380\u2010022\u201001719\u2010z"},{"key":"e_1_2_11_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cpnec.2024.100242"}],"container-title":["Diabetes, Obesity and Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dom-pubs.pericles-prod.literatumonline.com\/doi\/pdf\/10.1111\/dom.70340","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/dom-pubs.pericles-prod.literatumonline.com\/doi\/full-xml\/10.1111\/dom.70340","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/dom-pubs.pericles-prod.literatumonline.com\/doi\/pdf\/10.1111\/dom.70340","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,29]],"date-time":"2026-01-29T20:48:49Z","timestamp":1769719729000},"score":1,"resource":{"primary":{"URL":"https:\/\/dom-pubs.pericles-prod.literatumonline.com\/doi\/10.1111\/dom.70340"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,15]]},"references-count":50,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,2]]}},"alternative-id":["10.1111\/dom.70340"],"URL":"https:\/\/doi.org\/10.1111\/dom.70340","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.1111\/DOM.70340\/v2\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/DOM.70340\/v1\/review4","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/DOM.70340\/v1\/review3","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/DOM.70340\/v1\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/DOM.70340\/v1\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/DOM.70340\/v2\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/DOM.70340\/v2\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/DOM.70340\/v2\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/DOM.70340\/v1\/decision1","asserted-by":"object"}]},"ISSN":["1462-8902","1463-1326"],"issn-type":[{"value":"1462-8902","type":"print"},{"value":"1463-1326","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12,15]]},"assertion":[{"value":"2025-10-19","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-11-19","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-12-15","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}