{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T11:22:14Z","timestamp":1788434534327,"version":"build-2803163510"},"reference-count":44,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,12,4]],"date-time":"2025-12-04T00:00:00Z","timestamp":1764806400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2025,12,4]],"date-time":"2025-12-04T00:00:00Z","timestamp":1764806400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["dom-pubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabetes Obesity Metabolism"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>Ramadan fasting poses challenges for patients with type 2 diabetes mellitus (T2DM) due to increased risks of hypoglycemia and metabolic fluctuations. Tirzepatide, a dual GIP\/GLP\u20101 receptor agonist, has shown marked efficacy in glycemic control and weight reduction. This study aimed to evaluate the safety and effectiveness of tirzepatide among Bangladeshi patients with T2DM during Ramadan fasting.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This prospective, multicentre, real\u2010world evidence study included 109 adult patients with T2DM who intended to fast during Ramadan and were prescribed tirzepatide 2.5\u2009mg weekly, either as monotherapy or in combination with other anti\u2010hyperglycemic agents. Data on glycemic parameters, anthropometrics, blood pressure, lipid profile, renal and liver function were collected at 2\u20136\u2009weeks before Ramadan and at 2\u20136\u2009weeks after the end of Ramadan, along with incidences of adverse events. Statistical analysis was performed using SPSS 25.0.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The mean age of the study participants was 40.7\u2009\u00b1\u200912.8 (SD) years with female predominance (69.7%). About 86.7% of the participants were obese. The mean HbA1c significantly decreased from 7.6% (before Ramadan) to 6.5% (after Ramadan) (mean change: \u22121.1%;\n                      <jats:italic>p<\/jats:italic>\n                      &lt;0.001). Fasting plasma glucose and 2\u2010h postprandial glucose also showed significant reductions by \u22122\u2009mmol\/L and\u2009\u2212\u20093.8\u2009mmol\/L, respectively (both\n                      <jats:italic>p<\/jats:italic>\n                      &lt;0.001). Mean body weight reduction was 5.3\u2009\u00b1\u20093.9\u2009kg (6.3% of baseline;\n                      <jats:italic>p<\/jats:italic>\n                      &lt;0.001). Mild gastrointestinal events occurred in ~12% of participants, with no hypoglycemia reported.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Tirzepatide demonstrated significant improvements in glycaemic control and body weight, with good tolerability, among patients with type 2 diabetes in Bangladesh who fasted during Ramadan.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/dom.70343","type":"journal-article","created":{"date-parts":[[2025,12,4]],"date-time":"2025-12-04T10:10:13Z","timestamp":1764843013000},"page":"1508-1516","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Safety and effectiveness of tirzepatide during Ramadan fasting: Real\u2010world evidence from patients with type 2 diabetes in Bangladesh"],"prefix":"10.1111","volume":"28","author":[{"given":"Muhammad Hafizur","family":"Rahman","sequence":"first","affiliation":[{"name":"Department of Endocrinology Popular Diagnostic Center  Dhaka Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7749-3542","authenticated-orcid":false,"given":"Shahjada","family":"Selim","sequence":"additional","affiliation":[{"name":"Department of Endocrinology Bangladesh Medical University  Dhaka Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Faria","family":"Afsana","sequence":"additional","affiliation":[{"name":"Department of Endocrinology BIRDEM General Hospital  Dhaka Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Md. Azizul","family":"Hoque","sequence":"additional","affiliation":[{"name":"Department of Endocrinology Shaheed Tajuddin Ahmad Medical College  Gazipur Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Saifuddin","sequence":"additional","affiliation":[{"name":"Department of Endocrinology Dhaka Medical College &amp; Hospital  Dhaka Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Md. 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