{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T05:10:20Z","timestamp":1791868220721,"version":"4.3.4"},"reference-count":22,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,12,15]],"date-time":"2025-12-15T00:00:00Z","timestamp":1765756800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,12,15]],"date-time":"2025-12-15T00:00:00Z","timestamp":1765756800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100004339","name":"Sanofi","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004339","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["dom-pubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabetes Obesity Metabolism"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>To evaluate the efficacy and safety of transitioning from multiple daily injections (MDIs) insulin regimen to once\u2010daily, fixed\u2010ratio combination of basal insulin analog glargine 100\u2009U\/mL and a glucagon\u2010like peptide 1 receptor agonist lixisenatide (iGlarLixi) in people with type 2 diabetes (PwT2D).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>Insulin therapy DE\u2010intensificAtion with iglarLixi was a five\u2010centre, open\u2010label, parallel\u2010group, active comparator, phase IV randomised controlled trial with a 24\u2010week active treatment period. Eligible PwT2D (age 18\u201380\u2009years, HbA1c \u22649% [75\u2009mmol\/mol], total daily dose of insulin \u22640.8\u2009IU\/kg, and fasting C\u2010peptide above the lower limit of normal) were randomised in a 1:1 fashion to iGlarLixi initiation or continuation with MDI regimen. The primary endpoint was the mean change in HbA1c from baseline to 24\u2009weeks after randomisation between the two treatment groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Ninety individuals (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200945 in both treatment groups), 71\/91 (79.0%) male with mean (SD) age 66.2 (8.7) years, HbA1c 7.9 (1.0) % (62.8 [10.9] mmol\/mol), diabetes duration 17.5 (8.7) years and body mass index (BMI) 33.6 (5.5) kg\/m\n                      <jats:sup>2<\/jats:sup>\n                      were analysed. The mean (95% confidence interval) difference in the change in HbA1c between the iGlarLixi and the MDI group was \u22120.12 (\u22120.48, 0.23)% (\u22121.39 [\u22125.21, 2.43] mmol\/mol), indicating comparable glycaemic control in both treatment groups. Significant between\u2010group differences in favour of iGlarLixi were observed in body weight: \u22124.19 (\u22125.95, \u22122.43) kg, BMI: \u22121.49 (\u22122.11, \u22120.86) kg\/m\n                      <jats:sup>2<\/jats:sup>\n                      , total daily dose of insulin: \u221228.57 (\u221234.89, \u221222.24) IU, time spent in level 2 hyperglycaemia: \u22124.9 (\u22129.4, \u22120.34)%, and glycaemia risk index: \u221213.6 (\u221225.1, \u22122.1).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Insulin therapy simplification from MDI regimen to once\u2010daily iGlarLixi is an efficient and safe treatment option for PwT2D.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/dom.70362","type":"journal-article","created":{"date-parts":[[2025,12,15]],"date-time":"2025-12-15T11:03:54Z","timestamp":1765796634000},"page":"1817-1825","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Insulin therapy\n                    <scp>DE<\/scp>\n                    \u2010\n                    <scp>intensificAtion<\/scp>\n                    with\n                    <scp>iGlarLixi<\/scp>\n                    : A phase 4, open\u2010label, parallel\u2010group randomised controlled trial"],"prefix":"10.1111","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3292-7586","authenticated-orcid":false,"given":"Peter","family":"Novodvorsk\u00fd","sequence":"first","affiliation":[{"name":"Diabetes Centre Institute for Clinical and Experimental Medicine (IKEM)  Prague Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lenka","family":"Thieme","sequence":"additional","affiliation":[{"name":"Diabetes Centre Institute for Clinical and Experimental Medicine (IKEM)  Prague Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivana","family":"La\u0148kov\u00e1","sequence":"additional","affiliation":[{"name":"Diabetes Centre Institute for Clinical and Experimental Medicine (IKEM)  Prague Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u0160t\u011bp\u00e1nka","family":"Frankov\u00e1","sequence":"additional","affiliation":[{"name":"Diabetes Centre Institute for Clinical and Experimental Medicine (IKEM)  Prague Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alica","family":"Vesel\u00e1","sequence":"additional","affiliation":[{"name":"EDUMED s.r.o.  N\u00e1chod Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emil","family":"Z\u00e1humensk\u00fd","sequence":"additional","affiliation":[{"name":"Internal and Diabetology Clinic  Vala\u0161sk\u00e9 Klobouky Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tom\u00e1\u0161","family":"Edelsberger","sequence":"additional","affiliation":[{"name":"Private Diabetology Clinic  Krnov Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie","family":"L\u00f6blov\u00e1","sequence":"additional","affiliation":[{"name":"Diaclinic s.r.o.  \u010cesk\u00e9 Bud\u011bjovice Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ond\u0159ej","family":"\u017di\u017eka","sequence":"additional","affiliation":[{"name":"Diabetes Centre Institute for Clinical and Experimental Medicine (IKEM)  Prague Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miroslav","family":"Vytasil","sequence":"additional","affiliation":[{"name":"Sanofi  Prague Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felipe","family":"Lauand","sequence":"additional","affiliation":[{"name":"General Medicines Sanofi  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mireille","family":"Bonnemaire","sequence":"additional","affiliation":[{"name":"General Medicines Sanofi  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Filip","family":"Hrub\u00fd","sequence":"additional","affiliation":[{"name":"Department of Data Science IKEM  Prague Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Milo\u0161","family":"Mr\u00e1z","sequence":"additional","affiliation":[{"name":"Diabetes Centre Institute for Clinical and Experimental Medicine (IKEM)  Prague Czech Republic"},{"name":"General University Hospital and First Faculty of Medicine Charles University  Prague Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0201-6888","authenticated-orcid":false,"given":"Martin","family":"Haluz\u00edk","sequence":"additional","affiliation":[{"name":"Diabetes Centre Institute for Clinical and Experimental Medicine (IKEM)  Prague Czech Republic"},{"name":"General University Hospital and First Faculty of Medicine Charles University  Prague Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,12,15]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-012-2534-0"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.2337\/dci18-0033"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.2337\/dci22-0034"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc09-1348"},{"key":"e_1_2_10_6_1","unstructured":"Sanofi.Suliqua Summary of Product Characteristics.2020https:\/\/www.medicines.org.uk\/emc\/product\/9871\/smpc. 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