{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T16:04:53Z","timestamp":1788969893925,"version":"build-2803163510"},"reference-count":46,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,12,28]],"date-time":"2025-12-28T00:00:00Z","timestamp":1766880000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,12,28]],"date-time":"2025-12-28T00:00:00Z","timestamp":1766880000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100007028","name":"Leona M. and Harry B. 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To explore the glucose\u2010stabilising potential of GIP in type 1 diabetes, we evaluated the effects of exogenous and endogenous GIP on plasma glucose excursions in a setting of excess prandial insulin and physical activity after meal ingestion.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>\n                      In a randomised, placebo\u2010controlled, double\u2010blind crossover design, 12 men with type 1 diabetes underwent three separate study days involving a 4.5\u2010h continuous intravenous infusion of GIP, the GIP receptor antagonist GIP(3\u201030)NH\n                      <jats:sub>2<\/jats:sub>\n                      , and placebo, respectively, during which ingestion of a standardised mixed meal with subcutaneous injection of excess prandial insulin (125% of normal dose) was followed by 30\u2009min of intermediate resistance bicycling (to increase the risk of postprandial hypoglycaemia).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The GIP infusion did not protect against hypoglycaemia, but compared to GIP(3\u201030)NH\n                      <jats:sub>2<\/jats:sub>\n                      infusion, it attenuated postprandial maximum plasma glucose by 1.5\u2009\u00b1\u20090.5\u2009mmol\/L (mean\u2009\u00b1\u2009standard error of the mean) (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.048). GIP(3\u201030)NH\n                      <jats:sub>2<\/jats:sub>\n                      did not exacerbate glucose excursions or risk of hypoglycaemia compared with placebo. The amount of glucose infused to avoid plasma glucose &lt;2.5\u2009mmol\/L was similar on all three study days. No differences were found in C\u2010peptide, insulin or glucagon levels.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      GIP did not prevent hypoglycaemia following excess prandial insulin and physical activity after meal ingestion in males with type 1 diabetes, but it reduced peak postprandial plasma glucose compared to GIP(3\u201030)NH\n                      <jats:sub>2<\/jats:sub>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/dom.70373","type":"journal-article","created":{"date-parts":[[2025,12,29]],"date-time":"2025-12-29T05:02:47Z","timestamp":1766984567000},"page":"1886-1898","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Glucose\u2010dependent insulinotropic polypeptide reduces postprandial glucose excursions but does not protect from hypoglycaemia in persons with type 1 diabetes\u2014A randomised placebo\u2010controlled study"],"prefix":"10.1111","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1625-3558","authenticated-orcid":false,"given":"Bj\u00f8rn","family":"Hoe","sequence":"first","affiliation":[{"name":"Center for Clinical Metabolic Research, Gentofte Hospital University of Copenhagen  Hellerup Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebastian M. N.","family":"Heimb\u00fcrger","sequence":"additional","affiliation":[{"name":"Center for Clinical Metabolic Research, Gentofte Hospital University of Copenhagen  Hellerup Denmark"},{"name":"Sanos  S\u00f8borg Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7880-8515","authenticated-orcid":false,"given":"L\u00e6rke S.","family":"Gasbjerg","sequence":"additional","affiliation":[{"name":"Center for Clinical Metabolic Research, Gentofte Hospital University of Copenhagen  Hellerup Denmark"},{"name":"Department of Biomedical Sciences, Faculty of Health and Medical Sciences University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amalie R.","family":"Lanng","sequence":"additional","affiliation":[{"name":"Center for Clinical Metabolic Research, Gentofte Hospital University of Copenhagen  Hellerup Denmark"},{"name":"Novo Nordisk A\/S  Bagsv\u00e6rd 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