{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T00:09:04Z","timestamp":1773014944937,"version":"3.50.1"},"reference-count":31,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,12,28]],"date-time":"2025-12-28T00:00:00Z","timestamp":1766880000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,12,28]],"date-time":"2025-12-28T00:00:00Z","timestamp":1766880000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["dom-pubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabetes Obesity Metabolism"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>We aimed to compare renal outcomes between patients with type 2 diabetes mellitus (T2DM) who were treated with sodium\u2010glucose cotransporter 2 (SGLT2) inhibitors and those on other glucose\u2010lowering drugs under routine clinical practice.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>IMPROVE was a multicentric, observational, prospective real\u2010world study conducted across 45 hospitals in China. Eligible patients were adults \u226518\u2009years with T2DM for \u226512\u2009months who were currently taking SGLT2 inhibitors or other glucose\u2010lowering drugs. Blood and urine samples were collected at baseline and 6\u2009months. The primary endpoint was the rate of change of eGFR compared with the baseline level after 6 months.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The study took place between September 2021 and September 2023. At baseline, mean glycated haemoglobin was 8.33%, and mean eGFR was 114.68\u2009mL\/min\/1.73\u2009m\n                      <jats:sup>2<\/jats:sup>\n                      . Among 5562 patients completing 6\u2009months follow\u2010up, the mean eGFR change was +1.2\u2009mL\/min\/1.73\u2009m\n                      <jats:sup>2<\/jats:sup>\n                      in the SGLT2 inhibitors group versus \u22126.0\u2009mL\/min\/1.73\u2009m\n                      <jats:sup>2<\/jats:sup>\n                      in controls (difference 8.0, 95% CI 5.7\u201310.4;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.0001). In the SGLT2 inhibitors group, the risk of an eGFR decline \u226525% was 18.9%, lower than the 22.8% observed in controls (RR 0.83, 95% CI 0.78\u20130.87). The composite outcome of improved glycaemic control plus stable renal function was achieved in 39.1% versus 35.0% (RR 1.12, 95% CI 1.06\u20131.18).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In this Chinese real\u2010world study of patients with T2DM, treatment with SGLT2 inhibitors was associated with a slower decline in kidney function compared with other glucose\u2010lowering drugs.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/dom.70413","type":"journal-article","created":{"date-parts":[[2025,12,29]],"date-time":"2025-12-29T04:55:59Z","timestamp":1766984159000},"page":"2203-2214","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Effects of\n                    <scp>SGLT2<\/scp>\n                    inhibitors on development and progression of kidney disease in Chinese patients with type 2 diabetes: A multicentre, prospective real\u2010world study"],"prefix":"10.1111","volume":"28","author":[{"given":"Yun","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Medical Identification Air Force Medical Center  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yajing","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Endocrinology First Medical Center of Chinese PLA General Hospital  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3344-3540","authenticated-orcid":false,"given":"Yiming","family":"Mu","sequence":"additional","affiliation":[{"name":"Department of Endocrinology First Medical Center of Chinese PLA General Hospital  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu","family":"Cheng","sequence":"additional","affiliation":[{"name":"Department of Endocrinology First 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