{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T00:09:31Z","timestamp":1773014971134,"version":"3.50.1"},"reference-count":34,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,1,5]],"date-time":"2026-01-05T00:00:00Z","timestamp":1767571200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,1,5]],"date-time":"2026-01-05T00:00:00Z","timestamp":1767571200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100004339","name":"Sanofi","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004339","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["dom-pubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabetes Obesity Metabolism"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>To evaluate the glycaemic outcomes and safety of insulin glargine 300\u2009U\/mL (Gla\u2010300) in Chinese people with uncontrolled type 2 diabetes (T2D) by baseline age and disease duration.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>INITIATION was a 24\u2010week, interventional, single\u2010arm study where adults with T2D (glycated haemoglobin [HbA1c] 7.5%\u201311.0%) received Gla\u2010300. This post\u2010hoc subgroup analysis assessed HbA1c change from baseline to week 24 (primary endpoint), other glycaemic endpoints, insulin dose, hypoglycaemia, body weight change, and treatment satisfaction (using the Diabetes Treatment Satisfaction Questionnaire [DTSQ]) by baseline age (&lt;60 or\u2009\u2265\u200960\u2009years) and disease duration (&lt;5, \u22655 to &lt;10 or \u226510\u2009years in insulin\u2010na\u00efve participants, and &lt;10, 10 to &lt;15 or \u226515\u2009years in those with prior basal insulin [BI]).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Of 568 participants, 191 were insulin\u2010na\u00efve and 377 had received prior BI. Over 24\u2009weeks, Gla\u2010300 improved HbA1c in all age and disease duration subgroups. The least squares mean HbA1c change ranged from \u22121.02% (\u221211.1\u2009mmol\/mol) to \u22121.55% (\u221216.9\u2009mmol\/mol) in insulin\u2010na\u00efve participants and from \u22120.55% (\u22126.0\u2009mmol\/mol) to \u22120.76% (\u22128.3\u2009mmol\/mol) in prior BI participants. HbA1c &lt;7.0% (&lt;53\u2009mmol\/mol) achievement (ranging from 19.5% to 40.7%), other glycaemic endpoints, insulin dose increases, body weight changes and DTSQ score improvements did not significantly differ across the majority of subgroups, and the hypoglycaemia risk remained low.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Gla\u2010300 improved glycaemic control with a low risk of hypoglycaemia in Chinese people with T2D across all ages and disease durations, including older individuals and those with long\u2010standing diabetes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/dom.70420","type":"journal-article","created":{"date-parts":[[2026,1,6]],"date-time":"2026-01-06T04:20:05Z","timestamp":1767673205000},"page":"2255-2264","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Effects of age and disease duration on the glycaemic outcomes and safety of insulin glargine 300\u2009U\/\n                    <scp>mL<\/scp>\n                    in people with type 2 diabetes in China: A post\u2010hoc analysis of the\n                    <scp>INITIATION<\/scp>\n                    study"],"prefix":"10.1111","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5682-2340","authenticated-orcid":false,"given":"Liming","family":"Chen","sequence":"first","affiliation":[{"name":"NHC Key Laboratory of Hormones and Development, Tianjin Key Laboratory of Metabolic Diseases, Chu Hsien\u2010I Memorial Hospital &amp; Tianjin Institute of Endocrinology Tianjin Medical University  Tianjin China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qiu","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Endocrinology First Affiliated Hospital of Anhui Medical University  Hefei China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-5883-7081","authenticated-orcid":false,"given":"Binhong","family":"Duan","sequence":"additional","affiliation":[{"name":"Department of Endocrinology Heilongjiang Provincial Hospital  Harbin China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5984-3342","authenticated-orcid":false,"given":"Xiaohong","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Endocrinology Zhejiang Provincial People's Hospital, People's Hospital of Hangzhou Medical College  Hangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hailong","family":"Wan","sequence":"additional","affiliation":[{"name":"Department of Endocrinology Panjin Central Hospital  Panjin China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Binhong","family":"Wen","sequence":"additional","affiliation":[{"name":"Department of Endocrinology People's Hospital of Liaoning Province  Liaoning China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jie","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Endocrinology Hebei PetroChina Central Hospital  Langfang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haixia","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism Diseases, Weifang People's Hospital First Affiliated Hospital of Weifang Medical University  Weifang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Caixian","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Endocrinology Sixth Affiliated Hospital of Guangzhou Medical University, Qingyuan People's Hospital  Qingyuan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weiwei","family":"Liu","sequence":"additional","affiliation":[{"name":"Sanofi Investment Co., Ltd.  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