{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T11:07:46Z","timestamp":1791976066096,"version":"4.4.0"},"reference-count":41,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,1,6]],"date-time":"2026-01-06T00:00:00Z","timestamp":1767657600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,1,6]],"date-time":"2026-01-06T00:00:00Z","timestamp":1767657600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["dom-pubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabetes Obesity Metabolism"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Efsubaglutide Alfa is a novel long\u2010acting glucagon\u2010like peptide\u20101 receptor agonist developed to promote weight loss and improve metabolic outcomes. This Phase 2a trial evaluated its efficacy, tolerability, safety, and pharmacokinetics (PK) in overweight and obese individuals unresponsive to lifestyle interventions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In this multicenter, randomized, double\u2010blind, placebo\u2010controlled, multiple\u2010ascending dose study, 50 participants were randomized (8:2) across five dose cohorts (5, 7.5, 10, 15, and 20\u2009mg) or placebo. Participants received once\u2010weekly subcutaneous injections of Efsubaglutide Alfa or placebo, with individualized dose escalation every 2\u2009weeks, followed by 4\u2009weeks at target doses. Primary endpoints were percentage change in body weight from baseline and the proportion achieving \u22655% weight loss. Secondary endpoints included changes in body composition and a metabolic composite index (BMI, waist circumference, blood pressure, lipid profiles). Tolerability, safety, immunogenicity, and PK were assessed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Findings<\/jats:title>\n                    <jats:p>\n                      Between 25 April 2024 and 18 November 2024, 50 individuals were randomly assigned. Mean baseline characteristics included age 36.3\u2009years, bodyweight 92.9\u2009kg, and BMI 33.0\u2009kg\/m\n                      <jats:sup>2<\/jats:sup>\n                      . Efsubaglutide Alfa produced a mean weight reduction of 7.16% (95% CI: \u22128.08 to \u22126.24) versus 0.86% with placebo. Overall, 82.5% of Efsubaglutide\u2010treated participants achieved \u22655% weight loss (vs. 0% placebo). Fat mass decreased by 4.47\u2009kg, and lean mass also declined by 2.00\u2009kg from baseline; however, the lean\u2010to\u2010fat mass ratio improved by 19.73 percentage points. BMI, waist circumference, and systolic blood pressure significantly decreased. Gastrointestinal adverse events were the most common, mostly mild to moderate, occurring primarily during dose escalation. No treatment\u2010related serious adverse events occurred. Efsubaglutide Alfa showed dose\u2010proportional PK.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Interpretation<\/jats:title>\n                    <jats:p>Efsubaglutide Alfa demonstrated significant weight\u2010loss efficacy, metabolic improvements, and a preferable tolerability and safety profile, supporting further clinical development for obesity and related metabolic disorders.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/dom.70429","type":"journal-article","created":{"date-parts":[[2026,1,6]],"date-time":"2026-01-06T08:42:32Z","timestamp":1767688952000},"page":"2339-2349","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Efficacy, tolerability, and safety of Efsubaglutide Alfa in participants with obesity or overweight (\n                    <scp>LIGHT<\/scp>\n                    1): A randomized, double\u2010blind, placebo\u2010controlled, ascending\u2010dose phase 2a trial"],"prefix":"10.1111","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0722-2349","authenticated-orcid":false,"given":"Fei","family":"Gao","sequence":"first","affiliation":[{"name":"Department of Endocrinology and Metabolism, Shanghai Jiao Tong University School of Medicine Affiliated Sixth People's Hospital, Shanghai Clinical Center for Diabetes, Shanghai Diabetes Institute, Shanghai Key Laboratory of Diabetes Mellitus  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingxia","family":"Yuan","sequence":"additional","affiliation":[{"name":"Beijing Friendship Hospital, Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nianrong","family":"Mi","sequence":"additional","affiliation":[{"name":"Central Hospital Affiliated to Shandong First Medical University  Jinan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danfeng","family":"Peng","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism, Shanghai Jiao Tong University School of Medicine Affiliated Sixth People's Hospital, Shanghai Clinical Center for Diabetes, Shanghai Diabetes Institute, Shanghai Key Laboratory of Diabetes Mellitus  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruihua","family":"Dong","sequence":"additional","affiliation":[{"name":"Beijing Friendship Hospital, Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenjun","family":"Hu","sequence":"additional","affiliation":[{"name":"Central Hospital Affiliated to Shandong First Medical University  Jinan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaolin","family":"Dong","sequence":"additional","affiliation":[{"name":"Central Hospital Affiliated to Shandong First Medical University  Jinan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingcheng","family":"Chen","sequence":"additional","affiliation":[{"name":"Beijing Friendship Hospital, Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yulong","family":"Xu","sequence":"additional","affiliation":[{"name":"Innogen Pharmaceutical Co., Ltd.  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