{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T20:54:11Z","timestamp":1789419251675,"version":"build-2803163510"},"reference-count":56,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,2,18]],"date-time":"2026-02-18T00:00:00Z","timestamp":1771372800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,2,18]],"date-time":"2026-02-18T00:00:00Z","timestamp":1771372800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["dom-pubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabetes Obesity Metabolism"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>People with chronic kidney disease (CKD) and diabetes are at high risk of cardiovascular disease (CVD). Aortic pulse wave velocity (Ao\u2010PWV) is an independent predictor of CVD. Cardiovascular outcome trials (CVOTs) with glucagon like peptide\u20101 receptor agonist (GLP\u20101 RA) class demonstrate notable differences, with lixisenatide having neutral effects as compared to longer acting GLP\u20101 RA. It is unknown if shorter acting GLP\u20101 RA have an impact on Ao\u2010PWV and if this may explain the discordance observed in GLP\u20101RA CVOTs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>We studied people with type 2 diabetes and CKD in a proof\u2010of\u2010concept single centre, randomised, double\u2010blind parallel\u2010group placebo\u2010controlled study that evaluated 24\u2009weeks' treatment with lixisenatide as compared to placebo on the primary endpoint of Ao\u2010PWV.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      In total, 101 participants (male 66%) were randomised of whom 90 were eligible for analyses (lixisenatide [\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200947] and placebo [\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200943]). Ao\u2010PWV did not change significantly from baseline after 24\u2009weeks of treatment with final mean (95% confidence intervals) of 9.65 (9.17, 10.13) m\/s with lixisenatide and 9.96 (9.45, 10.46) m\/s with placebo,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.38. Similarly, no significant changes were observed in cardio\u2010renal risk biomarkers including albuminuria and Klotho levels. HbA1c decreased with lixisenatide as compared to placebo.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In people with CKD and type 2 diabetes the use of short\u2010acting GLP\u20101 RA lixisenatide did not significantly influence Ao\u2010PWV. Further studies are needed to understand mechanisms that may explain discordance in CVOTs results observed with GLP\u20101 RA.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Clinical Trial Registration<\/jats:title>\n                    <jats:p>ISRCTN: ISRCTN97699312; EudraCT\/CTIS number: 2016\u2010001758\u201017.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/dom.70481","type":"journal-article","created":{"date-parts":[[2026,2,18]],"date-time":"2026-02-18T10:39:23Z","timestamp":1771411163000},"page":"2953-2961","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Effect of lixisenatide on arterial stiffness in people with type 2 diabetes and kidney disease: Results of a randomised controlled trial"],"prefix":"10.1111","volume":"28","author":[{"given":"Nikolaos","family":"Fountoulakis","sequence":"first","affiliation":[{"name":"School of 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