{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T16:21:57Z","timestamp":1789230117207,"version":"build-2803163510"},"reference-count":39,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T00:00:00Z","timestamp":1768867200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T00:00:00Z","timestamp":1768867200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100016573","name":"Japan Association for Diabetes Education and Care","doi-asserted-by":"publisher","award":["2024\u2010YNG\u2010031"],"award-info":[{"award-number":["2024\u2010YNG\u2010031"]}],"id":[{"id":"10.13039\/100016573","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003478","name":"Ministry of Health, Labour and Welfare","doi-asserted-by":"publisher","award":["23AA2003"],"award-info":[{"award-number":["23AA2003"]}],"id":[{"id":"10.13039\/501100003478","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["dom-pubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabetes Obesity Metabolism"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>We investigated whether dipeptidyl peptidase\u20104 inhibitor (DPP\u20104i) use was associated with a higher risk of acute pancreatitis compared with sodium\u2013glucose cotransporter 2 inhibitor (SGLT2i) use in antidiabetic medication\u2010na\u00efve individuals.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and methods<\/jats:title>\n                    <jats:p>In this target trial emulation study of medication\u2010na\u00efve individuals with diabetes from a Japanese claims database from April 2014 to August 2023, the risk of acute pancreatitis was compared between new users of DPP\u20104is and new users of SGLT2is. After adjusting for confounders using propensity score\u2010based overlap weighting, we used Cox proportional hazards models for hospitalization due to acute pancreatitis to estimate the hazard ratio (HR) and 95% confidence interval (CI) within the groups in both the intention\u2010to\u2010treat and per\u2010protocol analyses. We also calculated incidence rate differences (IRDs) per 1000 person\u2010years.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>This study included 26\u2009133 DPP4\u2010i and 6497 SGLT2i users. DPP\u20104i use was not significantly associated with a higher risk of acute pancreatitis compared with SGLT2i use; the adjusted HRs were 0.97 (95% CI, 0.51\u20131.83) and 1.11 (95% CI, 0.54\u20132.27), with IRDs of \u22120.05 (95% CI, \u22120.97 to 0.87) and 0.15 (95% CI, \u22120.86 to 1.15) per 1000 person\u2010years in the intention\u2010to\u2010treat and per\u2010protocol analyses, respectively.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Although small differences cannot be excluded given the width of the CIs for the estimated HRs, the small IRDs observed suggest that any potential difference, if present, is likely to be clinically modest. Therefore, acute pancreatitis risk may not be a major determinant when selecting initial therapy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/dom.70490","type":"journal-article","created":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T08:22:48Z","timestamp":1768897368000},"page":"3033-3043","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Risk of acute pancreatitis with\n                    <scp>DPP<\/scp>\n                    \u20104 inhibitors versus\n                    <scp>SGLT2<\/scp>\n                    inhibitors in medication\u2010na\u00efve individuals with diabetes: A target trial emulation"],"prefix":"10.1111","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-5515-6930","authenticated-orcid":false,"given":"Takashi","family":"Tatewaki","sequence":"first","affiliation":[{"name":"Department of Clinical Epidemiology and Health Economics School of Public Health, The University of Tokyo  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6480-3388","authenticated-orcid":false,"given":"Akira","family":"Okada","sequence":"additional","affiliation":[{"name":"Department of Prevention of Diabetes and Lifestyle\u2010Related Diseases Graduate School of Medicine, The University of Tokyo  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuya","family":"Kimura","sequence":"additional","affiliation":[{"name":"Department of Health Services Research Graduate School of Medicine, The University of Tokyo  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hideo","family":"Yasunaga","sequence":"additional","affiliation":[{"name":"Department of Clinical Epidemiology and Health Economics School of Public Health, The University of Tokyo  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,1,20]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc25-S009"},{"key":"e_1_2_9_3_1","unstructured":"National Institute for Health and Care Excellence.Type 2 diabetes in adults: management. 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