{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T12:53:59Z","timestamp":1784120039070,"version":"3.55.0"},"reference-count":29,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,2,6]],"date-time":"2026-02-06T00:00:00Z","timestamp":1770336000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,2,6]],"date-time":"2026-02-06T00:00:00Z","timestamp":1770336000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100009720","name":"Jerold B Katz Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009720","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100018190","name":"Cornell Atkinson Center for Sustainability, Cornell University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100018190","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["dom-pubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabetes Obesity Metabolism"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Transportation noise is increasingly recognized as a cardiometabolic stressor, but its relationship with type 2 diabetes mellitus (T2DM) remains poorly defined. We examined whether transportation noise exposure was associated with incident T2DM in a large, diverse U.S. healthcare system cohort.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We identified adults without baseline T2DM from the Houston Methodist Learning Health System Registry (2016\u20132023). Transportation noise exposure was assigned at the census block group level using the 2020\u2009U.S. Department of Transportation National Transportation Noise Map. Five noise categories were examined: Road, Rail, Aviation, Road plus Aviation and Total. Cox proportional hazards models estimated associations across predefined categories, Quiet (\u226445\u2009dB), Moderate (45\u201354\u2009dB) and Loud (\u226555\u2009dB), and per 10\u2009dB increase, adjusting for demographics, cardiometabolic risk factors, socioeconomic vulnerability and PM\u2082.\u2085.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Among 984\u2009658 adults (2.1 million person\u2010years), 39\u2009587 developed T2DM (1.88 per 100 person\u2010years). Loud rail noise (HR 1.14; 95% CI: 1.01\u20131.29) and loud total noise (HR 1.17; 95% CI: 1.03\u20131.33) were associated with higher T2DM risk. Continuous models showed similar patterns, with each 10\u2009dB increase in rail noise (HR 1.09; 95% CI: 1.05\u20131.13) and road noise (HR 1.04; 95% CI: 1.01\u20131.08) associated with a higher hazard of incident T2DM. Effect sizes were modest but internally consistent and aligned with prior environmental noise studies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Transportation noise, particularly rail noise, was associated with higher T2DM risk. Given plausible mechanisms involving sleep disruption and stress\u2010related neuroendocrine activation, these findings add to evidence linking environmental noise to metabolic health and motivate further studies to evaluate causality and potential benefits of noise mitigation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/dom.70499","type":"journal-article","created":{"date-parts":[[2026,2,6]],"date-time":"2026-02-06T08:01:11Z","timestamp":1770364871000},"page":"3105-3114","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Transportation noise exposure and incident type 2 diabetes: A retrospective cohort study in a large U.S. healthcare system"],"prefix":"10.1111","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-6784-754X","authenticated-orcid":false,"given":"Jad","family":"Ardakani","sequence":"first","affiliation":[{"name":"Center for Cardiovascular Computational and Precision Health (C3PH), Department of Cardiology Houston Methodist  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Izza","family":"Shahid","sequence":"additional","affiliation":[{"name":"Center for Cardiovascular Computational and Precision Health (C3PH), Department of Cardiology Houston Methodist  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rakesh","family":"Gullapelli","sequence":"additional","affiliation":[{"name":"Center for Cardiovascular Computational and Precision Health (C3PH), Department of Cardiology Houston Methodist  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-2808-4656","authenticated-orcid":false,"given":"Eman Nayaz","family":"Ahmed","sequence":"additional","affiliation":[{"name":"Center for Cardiovascular Computational and Precision Health (C3PH), Department of Cardiology Houston Methodist  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Budhaditya","family":"Bose","sequence":"additional","affiliation":[{"name":"Center for Cardiovascular Computational and Precision Health (C3PH), Department of Cardiology Houston Methodist  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Omar","family":"Hahad","sequence":"additional","affiliation":[{"name":"Department of Cardiology \u2013 Cardiology I University Medical Center of the Johannes Gutenberg\u2010University Mainz  Mainz Germany"},{"name":"German Center for Cardiovascular Research (DZHK), Partner Site Rhine\u2010Main  Mainz Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zain","family":"Moin","sequence":"additional","affiliation":[{"name":"School of Engineering Medicine Texas A&amp;M University  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan C.","family":"Nicolas","sequence":"additional","affiliation":[{"name":"Center for Health Data Science &amp; Analytics Houston Methodist  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zulqarnain","family":"Javed","sequence":"additional","affiliation":[{"name":"Center for Cardiovascular Computational and Precision Health (C3PH), Department of Cardiology Houston Methodist  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weichuan","family":"Dong","sequence":"additional","affiliation":[{"name":"Center for Cardiovascular Computational and Precision Health (C3PH), Department of Cardiology Houston Methodist  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jay E.","family":"Maddock","sequence":"additional","affiliation":[{"name":"Center for Health &amp; Nature  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun","family":"Hang","sequence":"additional","affiliation":[{"name":"Department of Environmental and Occupational Health Sciences, School of Public Health University of Texas Health Science Center at Houston  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Archana","family":"Sadhu","sequence":"additional","affiliation":[{"name":"Department of Medicine Houston Methodist Hospital  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanjay","family":"Rajagopalan","sequence":"additional","affiliation":[{"name":"Harrington Heart and Vascular Institute, University Hospitals, Cleveland, OH Case Cardiovascular Research Institute, Case Western Reserve University  Cleveland Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khurram","family":"Nasir","sequence":"additional","affiliation":[{"name":"Center for Cardiovascular Computational and Precision Health (C3PH), Department of Cardiology Houston Methodist  Houston Texas USA"},{"name":"Methodist\u2010Rice Digital Health Institute Houston Methodist  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sadeer","family":"Al\u2010Kindi","sequence":"additional","affiliation":[{"name":"Center for Cardiovascular Computational and Precision Health (C3PH), Department of Cardiology Houston Methodist  Houston Texas USA"},{"name":"Center for Health &amp; Nature  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,2,6]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-023-02278-8"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41574-020-0381-5"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.2337\/dci20-0053"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.123.067461"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2017.12.015"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-8587(23)00361-3"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dyx020"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurjpc\/zwae320"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1289\/ehp.1205503"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1289\/EHP9146"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.envint.2020.106364"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2025.47119"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajpc.2024.100678"},{"key":"e_1_2_12_15_1","volume-title":"National Transportation Noise Map: 2020","author":"U.S. Department of Transportation, Bureau of Transportation Statistics","year":"2020"},{"key":"e_1_2_12_16_1","unstructured":"Centers for Disease Control and Prevention\/Agency for Toxic Substances and Disease Registry.Social Vulnerability Index (SVI).https:\/\/www.atsdr.cdc.gov\/placeandhealth\/svi\/index.html(accessed May 14 2025)."},{"key":"e_1_2_12_17_1","volume-title":"Protective Noise Levels: Condensed Version of the EPA Levels Document","author":"U.S. Environmental Protection Agency","year":"1978"},{"key":"e_1_2_12_18_1","volume-title":"Environmental Noise Guidelines for the European Region","author":"World Health Organization","year":"2018"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc11-1155"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11356-020-09826-6"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.envres.2022.113477"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psyneuen.2021.105347"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psyneuen.2021.105331"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.envint.2018.05.036"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.envres.2025.121805"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/jes.2015.56"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep24717"},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.1121\/1.4983302"},{"key":"e_1_2_12_29_1","doi-asserted-by":"publisher","DOI":"10.1186\/1476-069X-12-89"},{"key":"e_1_2_12_30_1","doi-asserted-by":"publisher","DOI":"10.1289\/EHP898"}],"container-title":["Diabetes, Obesity and Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dom-pubs.pericles-prod.literatumonline.com\/doi\/pdf\/10.1111\/dom.70499","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/dom-pubs.pericles-prod.literatumonline.com\/doi\/full-xml\/10.1111\/dom.70499","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/dom-pubs.pericles-prod.literatumonline.com\/doi\/pdf\/10.1111\/dom.70499","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T04:26:20Z","timestamp":1773807980000},"score":1,"resource":{"primary":{"URL":"https:\/\/dom-pubs.pericles-prod.literatumonline.com\/doi\/10.1111\/dom.70499"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,6]]},"references-count":29,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026,4]]}},"alternative-id":["10.1111\/dom.70499"],"URL":"https:\/\/doi.org\/10.1111\/dom.70499","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.1111\/DOM.70499\/v3\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/DOM.70499\/v2\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/DOM.70499\/v2\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/DOM.70499\/v1\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/DOM.70499\/v2\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/DOM.70499\/v1\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/DOM.70499\/v3\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/DOM.70499\/v1\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/DOM.70499\/v2\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/DOM.70499\/v1\/review4","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/DOM.70499\/v1\/review3","asserted-by":"object"}]},"ISSN":["1462-8902","1463-1326"],"issn-type":[{"value":"1462-8902","type":"print"},{"value":"1463-1326","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2,6]]},"assertion":[{"value":"2025-09-04","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-10","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-02-06","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}