{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T14:48:27Z","timestamp":1790606907472,"version":"4.1.0"},"reference-count":28,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,2,9]],"date-time":"2026-02-09T00:00:00Z","timestamp":1770595200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,2,9]],"date-time":"2026-02-09T00:00:00Z","timestamp":1770595200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["dom-pubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabetes Obesity Metabolism"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>The duodenum plays a central role in metabolic regulation, influencing insulin sensitivity, and glucose homeostasis. In type 2 diabetes (T2D), structural and functional abnormalities of the duodenal mucosa (\u201cdiabetic duodenopathy\u201d) are increasingly recognized as contributors to insulin resistance and dysglycaemia. Non\u2010thermal duodenal cellular regeneration using pulsed electric field (PEF) therapy offers a novel approach to restore metabolic signalling and target the underlying pathophysiology of T2D.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and methods<\/jats:title>\n                    <jats:p>\n                      An integrated analysis of two parallel, open\u2010label, multicentre feasibility studies evaluated the safety, feasibility, and metabolic effects of PEF\u2010based duodenal therapy in adults with uncontrolled T2D treated with non\u2010insulin medications. Eligible participants (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200971) were 18\u201370\u2009years old, with body mass index 24\u201340\u2009kg\/m\n                      <jats:sup>2<\/jats:sup>\n                      and glycated haemoglobin (HbA1c) 7.5%\u201311.0% (58\u201397\u2009mmol\/mol). Participants underwent endoscopic, catheter\u2010based PEF therapy to the duodenal wall (600 or 750\u2009V, single or double application) and were followed for 48\u2009weeks. The primary endpoint was the incidence of device\u2010 or procedure\u2010related serious adverse events (SAEs).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>No device\u2010 or procedure\u2010related SAEs were reported, demonstrating a favourable safety profile. Higher\u2010energy dosing, double applications, and use of the second\u2010generation catheter yielded greater and sustained metabolic improvements through 48\u2009weeks, including reductions in HbA1c, fasting glucose, weight, and markers of insulin resistance. Continuous glucose monitoring showed sustained increases in time\u2010in\u2010range and reduced glycaemic variability.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>PEF\u2010based duodenal regeneration therapy was safe, technically feasible, and associated with durable metabolic improvements over 48\u2009weeks. These findings support further evaluation of duodenal electroporation as a novel, minimally invasive approach for managing T2D.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/dom.70533","type":"journal-article","created":{"date-parts":[[2026,2,9]],"date-time":"2026-02-09T09:06:41Z","timestamp":1770628001000},"page":"3367-3376","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Safety, feasibility, and dose\u2010dependent metabolic effects of endoscopic duodenal pulsed electric field therapy in adults with type 2 diabetes: Results from two multicentre proof\u2010of\u2010concept studies"],"prefix":"10.1111","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0870-4032","authenticated-orcid":false,"given":"David N.","family":"O'Neal","sequence":"first","affiliation":[{"name":"Department of Medicine St Vincent's Hospital, University of Melbourne  Fitzroy Victoria Australia"},{"name":"Department of 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