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It can progress to metabolic dysfunction\u2010associated steatohepatitis (MASH) and fibrosis, cirrhosis and even hepatocellular carcinoma. However, most patients with non\u2010cirrhotic MASLD die from extrahepatic causes, particularly cardiovascular disease and non\u2010hepatic cancers, underscoring the need for a holistic approach to surveillance and treatment. Emerging research on MASLD has revealed a substantial heterogeneity in the MASLD population, driven by sex\u2010specific factors, genetic susceptibility, cardiometabolic risk profile, lifestyle and socio\u2010economic determinants, highlighting the necessity of individualised and holistic management of MASLD patients. Although lifestyle intervention remains the cornerstone of MASLD, the pharmacotherapeutic landscape is rapidly evolving, with resmetirom and semaglutide now approved for non\u2010cirrhotic MASH with moderate\u2010to\u2010advanced fibrosis. In addition, metabolic\/bariatric surgery has proven to be a highly effective option for patients with MASH. Given its close association with cardiometabolic and malignant comorbidities, MASLD requires individualised, holistic management integrating hepatic and extrahepatic risks. Multiprofessional care, involving among others behavioural therapists, dieticians and physiotherapists, may improve outcomes of lifestyle interventions, particularly in high\u2010risk settings. A stepwise and integrated care model combining early case\u2010finding, risk stratification, and tailored lifestyle and pharmacological interventions is essential to address both hepatic and extrahepatic complications. This review summarises the current understanding of MASLD heterogeneity, clinical assessment, and therapeutic advances, and outlines principles for individualised and coordinated care.<\/jats:p>","DOI":"10.1111\/dom.70545","type":"journal-article","created":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T09:12:04Z","timestamp":1770801124000},"page":"46-62","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Providing holistic care for patients with\n                    <scp>m<\/scp>\n                    etabolic dysfunction\u2010associated steatotic liver disease\/metabolic dysfunction\u2010associated steatohepatitis: Key aspects of clinical assessment and how to develop individualised care plans for surveillance and interventions"],"prefix":"10.1111","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1075-5592","authenticated-orcid":false,"given":"Lanlan","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Hepatology and Gastroenterology Campus Virchow\u2010Klinikum (CVK) and Campus Charit\u00e9 Mitte (CCM), Charit\u00e9 \u2010 Universit\u00e4tsmedizin Berlin  Berlin Germany"},{"name":"Department of Hepatobiliary and Pancreatic Surgery General Surgery Center, the First Hospital of Jilin University  Changchun China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Horn","sequence":"additional","affiliation":[{"name":"Department of Hepatology and Gastroenterology Campus Virchow\u2010Klinikum (CVK) and Campus Charit\u00e9 Mitte (CCM), Charit\u00e9 \u2010 Universit\u00e4tsmedizin Berlin  Berlin Germany"},{"name":"BIH Biomedical Innovation Academy, BIH Charit\u00e9 Digital Clinician Scientist Program Berlin Institute of Health at 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