{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T03:17:23Z","timestamp":1792120643131,"version":"4.4.0"},"reference-count":25,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T00:00:00Z","timestamp":1770854400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T00:00:00Z","timestamp":1770854400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["dom-pubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabetes Obesity Metabolism"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>Despite the established efficacy of tirzepatide in randomised controlled trials, real\u2010world effectiveness data in Japanese patients remain limited. This study evaluated the real\u2010world effectiveness and safety of tirzepatide in Japanese patients with type 2 diabetes over 52\u2009weeks.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>This multi\u2010site retrospective cohort study analysed 203 Japanese patients with type 2 diabetes who initiated tirzepatide at three outpatient clinics between July 2023 and August 2024. The primary endpoint was HbA1c change at 52\u2009weeks. Subgroup analyses were performed on 22 predefined patient characteristics.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The mean baseline HbA1c was 7.7%, and the mean body mass index was 29.1\u2009kg\/m\n                      <jats:sup>2<\/jats:sup>\n                      . Most patients (82.3%) had prior antidiabetic therapy, including insulin (30.0%). The overall mean HbA1c reduction was \u22120.91% (95% confidence interval: \u22121.08 to \u22120.74,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001), with 61.2% achieving &lt;60;7.0%. Incretin\u2010naive patients achieved greater reductions than GLP\u20101 RA switchers (\u22121.19% vs. \u22120.65%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.005). The mean weight loss was \u22123.4 kg. The treatment persistence rate was 92.6%. Gastrointestinal adverse events occurred in 6.4% of patients, and no hypoglycaemia was documented.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Tirzepatide demonstrated clinically meaningful HbA1c reductions with favourable safety profiles in Japanese patients. The effectiveness was consistent across diverse subgroups, supporting its integration into diabetes management in Japan.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/dom.70550","type":"journal-article","created":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T08:01:37Z","timestamp":1770883297000},"page":"3703-3715","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Real\u2010world effectiveness and safety of tirzepatide in Japanese patients with type 2 diabetes: A multi\u2010site retrospective study"],"prefix":"10.1111","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-8062-1365","authenticated-orcid":false,"given":"Yusuke","family":"Minakata","sequence":"first","affiliation":[{"name":"Diabetes and Endocrinology Kameda Medical Center  Kamogawa Japan"},{"name":"Juntendo University Urayasu Hospital  Urayasu Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masaki","family":"Miura","sequence":"additional","affiliation":[{"name":"Diabetes and Endocrinology Kameda Medical Center  Kamogawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nobuhiro","family":"Nakatake","sequence":"additional","affiliation":[{"name":"Diabetes and Endocrinology Kameda Medical Center  Kamogawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masahiro","family":"Masuzawa","sequence":"additional","affiliation":[{"name":"Diabetes and Endocrinology Kameda Medical Center  Kamogawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,2,12]]},"reference":[{"key":"e_1_2_9_2_1","volume-title":"IDF Diabetes Atlas","author":"International Diabetes 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