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Beyond its classical insulinotropic actions, GLP\u20101 enhances cardiovascular, renal, hepatic, and central nervous system (CNS) functions, thereby integrating multi\u2010organ metabolic responses. Emerging evidence highlights the critical role of microRNAs (miRNAs) as epigenetic regulators of GLP\u20101 signalling, influencing receptor expression, \u03b2\u2010cell survival, hypothalamic appetite circuits, and peripheral tissue metabolism. miRNAs act bidirectionally: they can attenuate GLP\u20101 receptor (GLP\u20101R) expression, contributing to \u2018incretin resistance\u2019 in obesity and type 2 diabetes (T2DM), or mediate GLP\u20101\u2013induced transcriptional adaptations that enhance insulin secretion, lipid oxidation, and energy expenditure. This review synthesizes current knowledge of GLP\u20101 physiology, receptor signalling, and the miRNA\u2010mediated regulatory network, with a focus on mechanisms underlying obesity and metabolic disorders. 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