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A diagnosis of T1D is typically associated with children and adolescents, yet half of all diagnoses of T1D are made in adults. In children and adolescents, T1D is often first recognized following hospitalization for diabetic ketoacidosis (DKA), which occurs in approximately 20%\u201350% of new\u2010onset T1D for people younger than 18\u2009years of age in Europe. For adults with new\u2010onset T1D, DKA rates of up to 24% are estimated. Early\u2010stage T1D, during the asymptomatic period, can be detected through screening for multiple islet autoantibodies in blood samples, including capillary and venous samples, and such programs are made more popular by the availability of disease\u2010modifying therapies for early\u2010stage T1D. For individuals who screen positive for early\u2010stage T1D, participation in monitoring programs can greatly reduce the incidence of DKA once symptomatic hyperglycemia develops, as well as reducing severity of symptoms of T1D at onset. Education and awareness of the clinically relevant features of symptomatic T1D can also support the psychological wellbeing of people with early\u2010stage T1D and minimize distress at the point when insulin treatment is necessary. All of these consequences come with a predicted reduced burden of healthcare costs for managing T1D at a population level, and general population screening for islet autoantibodies is underway. In this European perspective, we discuss the imperatives and the components of implementation of general population screening for early\u2010stage T1D.<\/jats:p>","DOI":"10.1111\/dom.70569","type":"journal-article","created":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T06:00:36Z","timestamp":1773381636000},"page":"3535-3556","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["An international consensus on screening and monitoring early\u2010stage type 1 diabetes: A roadmap to European implementation"],"prefix":"10.1111","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6611-8245","authenticated-orcid":false,"given":"Sufyan","family":"Hussain","sequence":"first","affiliation":[{"name":"Department of Diabetes, School of Cardiovascular, Metabolic Medicine and Sciences King's College London  London UK"},{"name":"Department of Diabetes and Endocrinology Guy's &amp; St Thomas' NHS Foundation Trust  London UK"},{"name":"Institute of Diabetes, Endocrinology and Obesity King's Health Partners  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy","family":"Tree","sequence":"additional","affiliation":[{"name":"Department of Immunobiology, School of Immunology and Microbial Sciences King's College London  London UK"},{"name":"National Institute for Health Research Biomedical Research Centre, Guy's and St. Thomas' NHS Foundation Trust and Kings College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4055-5233","authenticated-orcid":false,"given":"Chantal","family":"Mathieu","sequence":"additional","affiliation":[{"name":"Clinical and Experimental Endocrinology University of Leuven  Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomasz","family":"Klupa","sequence":"additional","affiliation":[{"name":"Department of Metabolic Diseases, Centre for Advanced Technologies in Diabetes Jagiellonian University Medical College  Krakow Poland"},{"name":"Department of Metabolic Diseases, Psychodiabetology Unit Jagiellonian University Medical College  Krakow Poland"},{"name":"Department of Metabolic Diseases and Diabetology University Hospital in Krak\u00f3w  Krakow Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8081-188X","authenticated-orcid":false,"given":"Anna\u2010Kaisa","family":"Tuomaala","sequence":"additional","affiliation":[{"name":"Pediatric Research Center Helsinki University Children's Hospital  Helsinki Finland"},{"name":"Faculty of Medicine University of Helsinki  Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maartje","family":"de Wit","sequence":"additional","affiliation":[{"name":"Medical Psychology, Amsterdam UMC, Location Vrije Universiteit Amsterdam  Amsterdam the Netherlands"},{"name":"Mental Health, Amsterdam Public Health  Amsterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olga","family":"Kordonouri","sequence":"additional","affiliation":[{"name":"Kinder\u2010 und Jugendkrankenhaus auf der Bult  Hannover Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6590-245X","authenticated-orcid":false,"given":"Katarina","family":"Braune","sequence":"additional","affiliation":[{"name":"Hasso Plattner Institute for Digital Engineering University of Potsdam  Potsdam Germany"},{"name":"Institute of Medical Informatics, Charit\u00e9 \u2010 Universit\u00e4tsmedizin  Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaivir","family":"Pall","sequence":"additional","affiliation":[{"name":"INNODIA Patient Advisory Committee  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis","family":"Castano","sequence":"additional","affiliation":[{"name":"Hospital Universitario Cruces, Universidad del Pa\u00eds Vasco, IIS Biobizcaia, CIBERDEN, CIBERER, Endo\u2010ERN  Baracaldo Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel E. 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