{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T21:28:22Z","timestamp":1789680502598,"version":"4.0.1"},"reference-count":24,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,2,23]],"date-time":"2026-02-23T00:00:00Z","timestamp":1771804800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,2,23]],"date-time":"2026-02-23T00:00:00Z","timestamp":1771804800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100004312","name":"Eli Lilly and Company","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004312","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["dom-pubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabetes Obesity Metabolism"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>To evaluate the steady\u2010state pharmacokinetics (PK) and glucodynamic effects of insulin efsitora alfa (efsitora) over a weekly interval in adults with type 2 diabetes (T2D).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>\n                      This open\u2010label, multiple dose, euglycaemic clamp study was conducted in 56 insulin na\u00efve adults with T2D (mean [\u00b1SD] age, 61.9\u2009\u00b1\u20095.98\u2009years; HbA1c, 7.1\u2009\u00b1\u20090.64%; BMI, 31.7\u2009\u00b1\u20093.20\u2009kg\/m\n                      <jats:sup>2<\/jats:sup>\n                      ). Following a dose\u2010finding lead\u2010in period with once\u2010daily degludec, eligible participants received a one\u2010time loading dose of 12\u2009U\/kg efsitora followed by 9 weekly doses of 4\u2009U\/kg. Three 24\u2010h clamps were conducted on Days 1, 4, and 7 after the last efsitora dose. Model\u2010based interpolation was used to derive the glucodynamic profile over the weekly dosing interval at steady\u2010state.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Model\u2010predicted pharmacokinetic steady\u2010state was achieved between the 4th and 6th weekly dose of efsitora when using a one\u2010time loading dose. At steady\u2010state, the PK profile over the week had a low peak\u2010to\u2010trough ratio of 1.16, with a half\u2010life of 19\u2009days. The model\u2010predicted glucose infusion rate profile, over the weekly dosing interval, demonstrated a stable glucose\u2010lowering effect of efsitora. The maximum glucose infusion rate occurred between Days 4 and 5. Efsitora showed an even distribution of the glucose\u2010lowering effect within a weekly dosing interval, with a peak\u2010to\u2010trough ratio of 1.07. Efsitora was safe and well tolerated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Efsitora demonstrated a flat, prolonged PK profile, providing a consistent level of insulin exposure at steady\u2010state and resulting in a stable glucose\u2010lowering response across the weekly dosing interval.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/dom.70585","type":"journal-article","created":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T12:02:17Z","timestamp":1772971337000},"page":"4010-4018","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Characterisation of steady\u2010state pharmacokinetics and glucodynamics of once\u2010weekly insulin efsitora alfa in individuals with type 2 diabetes"],"prefix":"10.1111","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5434-7905","authenticated-orcid":false,"given":"Jennifer","family":"Leohr","sequence":"first","affiliation":[{"name":"Eli Lilly and Company  Indianapolis Indiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oliver","family":"Klein","sequence":"additional","affiliation":[{"name":"Profil  Neuss Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8346-2037","authenticated-orcid":false,"given":"Tim","family":"Heise","sequence":"additional","affiliation":[{"name":"Profil  Neuss Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8843-5452","authenticated-orcid":false,"given":"Eric","family":"Zijlstra","sequence":"additional","affiliation":[{"name":"Profil  Neuss Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juliana M.","family":"Bue\u2010Valleskey","sequence":"additional","affiliation":[{"name":"Eli Lilly and Company  Indianapolis Indiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Subha","family":"Suriyapperuma","sequence":"additional","affiliation":[{"name":"Eli Lilly and Company  Indianapolis Indiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryan","family":"Jarrett","sequence":"additional","affiliation":[{"name":"Eli Lilly and Company  Indianapolis Indiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Douglas","family":"James","sequence":"additional","affiliation":[{"name":"Eli Lilly and Company  Indianapolis Indiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Micheal","family":"Case","sequence":"additional","affiliation":[{"name":"Eli Lilly and Company  Indianapolis Indiana 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