{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T09:44:39Z","timestamp":1790675079973,"version":"4.1.0"},"reference-count":37,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,2,24]],"date-time":"2026-02-24T00:00:00Z","timestamp":1771891200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,2,24]],"date-time":"2026-02-24T00:00:00Z","timestamp":1771891200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["dom-pubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabetes Obesity Metabolism"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>This study aims to examine weight\u2010loss history and pre\u2010treatment concerns, and their associations with current functioning and well\u2010being in adults undergoing incretin\u2010based pharmacotherapy for obesity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>This cross\u2010sectional study analysed 411 adults treated with three different incretin\u2010based medications. Demographics, previous weight\u2010loss interventions, barriers to earlier attempts, reasons for initiating incretin therapy, treatment characteristics and Treatment\u2010Related Impact Measure for Weight (TRIM\u2010Weight) total scores were assessed. Associations between specific pre\u2010treatment concerns and functioning and well\u2010being were analysed using univariate models and a multivariable regression model that adjusted for treatment related variables.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Participants had a median age of 39\u2009years (IQR 33\u201347), 79.1% were women, and the median BMI was 36.3\u2009kg\/m\n                      <jats:sup>2<\/jats:sup>\n                      (IQR 32.2\u201342.3). The median TRIM\u2010Weight total score was 68.2 (IQR 64.0\u201373.4). Most respondents (95.1%) had attempted weight loss, typically through combined diet and physical activity (71.8%), intermittent fasting (69.6%) and digital tracking tools (65.7%). In fully adjusted models, fear of side effects (\n                      <jats:italic>\u03b2<\/jats:italic>\n                      \u2009=\u2009\u22123.53, 95% CI \u22124.05 to \u22123.01), concerns about cost (\n                      <jats:italic>\u03b2<\/jats:italic>\n                      \u2009=\u2009\u22120.92, 95% CI \u22121.37 to \u22120.47) and injection anxiety (\n                      <jats:italic>\u03b2<\/jats:italic>\n                      \u2009=\u2009\u22120.67, 95% CI \u22121.16 to \u22120.18) were associated with lower functioning and well\u2010being. Doubts regarding effectiveness showed a small positive association (\n                      <jats:italic>\u03b2<\/jats:italic>\n                      \u2009=\u20090.61, 95% CI 0.03\u20131.19).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Among retrospectively reported pre\u2010treatment concerns, fear of side effects, treatment costs and injection anxiety were most strongly associated with lower functioning and well\u2010being, whereas moral or psychosocial concerns showed no independent associations after multivariable adjustment.<\/jats:p>\n                  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