{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T04:31:00Z","timestamp":1787027460244,"version":"build-2736575974"},"reference-count":20,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T00:00:00Z","timestamp":1772064000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T00:00:00Z","timestamp":1772064000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["dom-pubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabetes Obesity Metabolism"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>Evogliptin, a dipeptidyl peptidase\u20104 inhibitor with a glucose\u2010dependent mechanism of action, is widely used as a monotherapy or in combination with other agents. However, observational studies in routine clinical settings remain limited. This study aimed to evaluate the effectiveness and safety of evogliptin in combination with other antidiabetic agents frequently used in clinical practice.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This study was conducted in 51 hospitals in South Korea. We evaluated evogliptin in three groups: the evogliptin add\u2010on, evogliptin\u2010switching, and initial combination groups. The primary endpoint was the change in haemoglobin A1c (HbA1c) levels (%) from baseline to 12\u2009weeks. The change in HbA1c (%) levels from baseline to 24\u2009weeks was a secondary endpoint in the extended study. Proportions of patients achieving the HbA1c target, changes in fasting and postprandial glucose levels, and safety endpoints were also evaluated. Between\u2010group comparisons were performed between the add\u2010on and initial combination groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>In the 1596 patients of the effectiveness set, the mean changes in HbA1c levels at 12\u2009weeks were \u22120.8%\u2009\u00b1\u20091.2%, \u22120.3%\u2009\u00b1\u20090.8% and \u22121.9%\u2009\u00b1\u20091.4% for the evogliptin add\u2010on, evogliptin\u2010switching and initial combination groups, respectively. Among the 1920 patients in the safety set, 23 experienced adverse drug reactions, and there was no significant difference among the three groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Evogliptin reduces blood glucose levels and is well\u2010tolerated when used as an add\u2010on, as a switch from other dipeptidyl peptidase 4 inhibitors, or as part of an initial combination therapy in patients with type 2 diabetes mellitus.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/dom.70601","type":"journal-article","created":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T10:58:11Z","timestamp":1772967491000},"page":"4112-4120","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Effectiveness and Safety of Evogliptin in Patients With Type 2 Diabetes Mellitus: A Multicenter, Prospective, Observational Study"],"prefix":"10.1111","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8693-1038","authenticated-orcid":false,"given":"Jun Hwa","family":"Hong","sequence":"first","affiliation":[{"name":"Department of Internal Medicine Daejeon Eulji Medical Center, Eulji University  Daejeon Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sung Hoon","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Hanyang University Guri Hospital, Hanyang University College of Medicine  Guri Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ki\u2010Hyun","family":"Baek","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Yeouido St. Mary's Hospital, College of Medicine, the Catholic University of Korea  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"JaeMyung","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Hallym University Kangnam Sacred Heart Hospital, Hallym University College of Medicine  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seung Jin","family":"Lee","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Internal Medicine Soonchunhyang University Cheonan Hospital  Cheonan Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyung\u2010Wook","family":"Kim","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Department of Internal Medicine St. Vincent's Hospital, College of Medicine, the Catholic University of Korea  Suwon Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kang Seo","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Daejeon Eulji Medical Center, Eulji University  Daejeon Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jung Han","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Sung Ae General Hospital  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"KyungWan","family":"Min","sequence":"additional","affiliation":[{"name":"Division of Endocrinology and Metabolism, Department of Internal Medicine Nowon Eulji Medical Center, Eulji University  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong Hwan","family":"Lee","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Internal Medicine Dong Rae Bong Seng Hospital  Busan Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koon Soon","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Daejeon Endo Internal Medicine  Daejeon Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min Soo","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Global Health Care Esoo Hospital  Asan Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji Hoon","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Hong Ik Hospital  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie\u2010Eun","family":"Lee","sequence":"additional","affiliation":[{"name":"Division of Endocrinology and Metabolism, Department of Internal Medicine CHA Gangnam Medical Center, CHA University  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2219-4083","authenticated-orcid":false,"given":"Jong Chul","family":"Won","sequence":"additional","affiliation":[{"name":"Division of Endocrinology and Metabolism, Department of Internal Medicine Gimpo Woori Hospital  Gimpo 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