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Patients with type 2 diabetes (HbA1c \u2265\u20096.5%, use of antidiabetic drugs, and\/or disease codes of type 2 diabetes) and preserved kidney function (estimated glomerular filtration rate [eGFR]\u2009\u2265\u200960\u2009mL\/min\/1.73\u2009m\n                      <jats:sup>2<\/jats:sup>\n                      , urinary protein &lt;\u20091+ and without past history of chronic kidney disease) were included. We compared the risk of new\u2010onset proteinuria among new users of empagliflozin, dapagliflozin and canagliflozin using the inverse probability of treatment weighting to adjust for baseline confounders and the inverse probability of censoring weighting to account for loss to follow\u2010up.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The mean age was 67.5\u2009\u00b1\u200910.3\u2009years, and 60% were men. The mean HbA1c level and eGFR were 7.56%\u2009\u00b1\u20091.32% and 75.0\u2009\u00b1\u20098.0\u2009mL\/min\/1.73\u2009m\n                      <jats:sup>2<\/jats:sup>\n                      , respectively. During the median follow\u2010up of 522 [263\u2013925] days, new\u2010onset proteinuria occurred in 43, 66 and 48 empagliflozin, dapagliflozin and canagliflozin users, respectively. Dapagliflozin showed a higher risk of new\u2010onset proteinuria (hazard ratio [HR], 1.64; 95% confidence interval [CI], 1.15\u20132.33) than empagliflozin, particularly in men (HR, 2.34; 95% CI, 1.53\u20133.58) (\n                      <jats:italic>p<\/jats:italic>\n                      for heterogeneity &lt;\u20090.01).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Empagliflozin was associated with a lower risk of new\u2010onset proteinuria compared with dapagliflozin. These findings underscore the importance of individualised SGLT2 inhibitor selection but require confirmation in randomised controlled trials.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/dom.70625","type":"journal-article","created":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T06:36:32Z","timestamp":1773124592000},"page":"4314-4325","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Comparison of\n                    <scp>SGLT2<\/scp>\n                    Inhibitors for New\u2010Onset Proteinuria Risk in Patients With Type 2 Diabetes and Preserved Kidney Function"],"prefix":"10.1111","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1783-8024","authenticated-orcid":false,"given":"Hiroki","family":"Nobayashi","sequence":"first","affiliation":[{"name":"Division of Public Health, Hygiene and Epidemiology, Faculty of Medicine Tohoku Medical and Pharmaceutical University  Sendai 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